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    eif-2D SUI1 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173964, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eif-2D
    Official Full Name
    SUI1 domain-containing protein
    Primary source
    WormBase:WBGene00016113
    Locus tag
    CELE_C25H3.4
    See related
    AllianceGenome:WB:WBGene00016113
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable translation initiation factor activity. Predicted to be involved in formation of translation preinitiation complex. Orthologous to human EIF2D (eukaryotic translation initiation factor 2D). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eif-2D in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (5691721..5693939)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial Neighboring gene Thioesterase domain-containing protein Neighboring gene Thioesterase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation. Sonobe Y, et al. Nat Commun, 2021 Oct 15. PMID 34654821, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of translation preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SUI1 domain-containing protein
    NP_495114.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5691721..5693939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062713.7 → NP_495114.3  SUI1 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495114.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18186
      Conserved Domains (4) summary
      cd11608
      Location:457 → 540
      eIF2D_C; C-terminal domain of eIF2D and related proteins
      cd11610
      Location:6 → 77
      eIF2D_N; N-terminal domain of eIF2D and related proteins
      COG2016
      Location:15 → 181
      Tma20; Predicted ribosome-associated RNA-binding protein Tma20, contains PUA domain [Translation, ribosomal structure and biogenesis]
      cl00607
      Location:58 → 176
      PUA; PUA domain
    Nucleotide Protein
    Heading Accession and Version

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