ufl-1 E3 UFM1-protein ligase 1 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ufl-1
Official Full Name: E3 UFM1-protein ligase 1 homolog
Primary source: WormBase:WBGene00015555
Locus tag: CELE_C06G3.9
See related: AllianceGenome:WB:WBGene00015555
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable UFM1 transferase activity. Predicted to be involved in negative regulation of NF-kappaB transcription factor activity; response to endoplasmic reticulum stress; and reticulophagy. Predicted to be active in endoplasmic reticulum membrane. Is expressed in intestine. Orthologous to human UFL1 (UFM1 specific ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ufl-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 12

Sequence:: Chromosome: IV; NC_003282.8 (7032696..7036859, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C06G3.9 (e-PCR)
- UniSTS:308501

C06G3.3 (e-PCR)
- UniSTS:315434

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables UFM1 ligase activity	IEA Inferred from Electronic Annotation more info
enables UFM1 transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ufmylation	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 UFM1-protein ligase 1 homolog

NP_501090.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

7032696..7036859 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068689.7 → NP_501090.1 E3 UFM1-protein ligase 1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501090.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17750

Conserved Domains (1) summary

pfam09743
Location:6 → 273

DUF2042; Uncharacterized conserved protein (DUF2042)