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    ent-3 Equilibrative Nucleoside Transporter [ Caenorhabditis elegans ]

    Gene ID: 179926, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ent-3
    Official Full Name
    Equilibrative Nucleoside Transporter
    Primary source
    WormBase:WBGene00010510
    Locus tag
    CELE_K02E11.1
    See related
    AllianceGenome:WB:WBGene00010510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable nucleoside transmembrane transporter activity. Predicted to be involved in nucleoside transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in histiocytosis-lymphadenopathy plus syndrome. Orthologous to human SLC29A2 (solute carrier family 29 member 2) and SLC29A3 (solute carrier family 29 member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ent-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    15
    Sequence:
    Chromosome: V; NC_003283.11 (14232281..14236042, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene tRNA-Gln Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional redundancy of two nucleoside transporters of the ENT family (CeENT1, CeENT2) required for development of Caenorhabditis elegans. Appleford PJ, et al. Mol Membr Biol, 2004 Jul-Aug. PMID 15371014
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables nucleoside transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleoside transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleoside transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Equilibrative Nucleoside Transporter
    NP_506521.2
    • Product from WormBase gene class ent;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14232281..14236042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074120.5 → NP_506521.2  Equilibrative Nucleoside Transporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506521.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21145
      Conserved Domains (2) summary
      pfam01733
      Location:434 → 723
      Nucleoside_tran; Nucleoside transporter
      cl21678
      Location:121 → 234
      ChlI; Subunit ChlI of Mg-chelatase
    Nucleotide Protein
    Heading Accession and Version

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