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    mcp-1 GDP-D-glucose phosphorylase 1 [ Caenorhabditis elegans ]

    Gene ID: 178982, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mcp-1
    Official Full Name
    GDP-D-glucose phosphorylase 1
    Primary source
    WormBase:WBGene00015678
    Locus tag
    CELE_C10F3.4
    See related
    AllianceGenome:WB:WBGene00015678
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GDP-D-glucose phosphorylase activity. Involved in glucose metabolic process. Located in cytoplasm. Is expressed in anterior hypodermis; nervous system; and reproductive system. Orthologous to human GDPGP1 (GDP-D-glucose phosphorylase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mcp-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    12
    Sequence:
    Chromosome: V; NC_003283.11 (5961874..5969173)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein-L-isoaspartate O-methyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antibody responses against the vaccine antigens Ov-103 and Ov-RAL-2 are associated with protective immunity to Onchocerca volvulus infection in both mice and humans. George PJ, et al. PLoS Negl Trop Dis, 2019 Sep. PMID 31525197, Free PMC Article
    2. The L-isoaspartyl-O-methyltransferase in Caenorhabditis elegans larval longevity and autophagy. Gomez TA, et al. Dev Biol, 2007 Mar 15. PMID 17187774, Free PMC Article
    3. A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals. Adler LN, et al. J Biol Chem, 2011 Jun 17. PMID 21507950, Free PMC Article
    4. Defective responses to oxidative stress in protein l-isoaspartyl repair-deficient Caenorhabditis elegans. Khare S, et al. Mech Ageing Dev, 2009 Oct. PMID 19682488, Free PMC Article
    5. The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival. Schulz A, et al. J Cell Biol, 2020 Feb 3. PMID 31968056, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival.
      Title: The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival.
    2. C15orf58 in humans and C10F3.4 in C. elegans display GDP-hexose phosphorylase activity but the major reaction catalyzed by these enzymes is the phosphorolysis of GDP-D-glucose to GDP and D-glucose 1-phosphate
      Title: A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GDP-D-glucose phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP-D-glucose phosphorylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP-D-glucose phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GDP-D-glucose phosphorylase 1
    NP_001023639.1
    • Confirmed by transcript evidence
    NP_001379651.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5961874..5969173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028468.4 → NP_001023639.1  GDP-D-glucose phosphorylase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023639.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16879, Q5ZR76
      Conserved Domains (1) summary
      cl14728
      Location:87 → 424
      DUF4922; Domain of unknown function (DUF4922)

    2. NM_001392523.1 → NP_001379651.1  GDP-D-glucose phosphorylase 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl14728
      Location:63 → 400
      DUF4922; Domain of unknown function (DUF4922)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5ZR76.1

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