prde-1 piRNA biogenesis factor prde-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: prde-1
Official Full Name: piRNA biogenesis factor prde-1
Primary source: WormBase:WBGene00008995
Locus tag: CELE_F21A3.5
See related: AllianceGenome:WB:WBGene00008995
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in positive regulation of piRNA transcription. Located in autosome. Is expressed in PLML; PLMR; germ cell; and germ line. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See prde-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 8

Sequence:: Chromosome: V; NC_003283.11 (15538244..15547086)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study showed that two essential piRNA factors, PRDE-1 and PRG-1/PIWI, inhibit axon regeneration in a gonad-independent and cell-autonomous manner.
Title: A Neuronal piRNA Pathway Inhibits Axon Regeneration in C. elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F21A3.4 (e-PCR)
- UniSTS:313090

F21A3.5 (e-PCR)
- UniSTS:319263

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of piRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in autosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: piRNA biogenesis factor prde-1

NP_506866.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

15538244..15547086

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074465.4 → NP_506866.3 piRNA biogenesis factor prde-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506866.3

Status: REVIEWED

UniProtKB/Swiss-Prot

O17828

Conserved Domains (2) summary

COG0515
Location:86 → 350

SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]

cl21453
Location:94 → 294

PKc_like; Protein Kinases, catalytic domain