U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    gpx-4 Glutathione peroxidase [ Caenorhabditis elegans ]

    Gene ID: 190801, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    gpx-4
    Official Full Name
    Glutathione peroxidase
    Primary source
    WormBase:WBGene00022377
    Locus tag
    CELE_Y94H6A.4
    See related
    AllianceGenome:WB:WBGene00022377
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable peroxidase activity. Predicted to be involved in cellular oxidant detoxification and response to oxidative stress. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; cerebral infarction; gastrointestinal system cancer (multiple); multiple myeloma; and type 2 diabetes mellitus. Orthologous to human GPX3 (glutathione peroxidase 3) and GPX5 (glutathione peroxidase 5). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See gpx-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (2672962..2675015, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Brix domain-containing protein;DUF1902 domain-containing protein;Uncharacterized protein Neighboring gene PRP16 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Toxicity of Three Optical Brighteners: Potential Pharmacological Targets and Effects on Caenorhabditis elegans. Castro-Sierra I, et al. Toxics, 2024 Jan 9. PMID 38251007, Free PMC Article
    2. Toxicity of atrazine- and glyphosate-based formulations on Caenorhabditis elegans. García-Espiñeira M, et al. Ecotoxicol Environ Saf, 2018 Jul 30. PMID 29550685
    3. Toxicity of nonylphenol and nonylphenol ethoxylate on Caenorhabditis elegans. De la Parra-Guerra A, et al. Ecotoxicol Environ Saf, 2020 Jan 15. PMID 31654870
    4. Deletion of the four phospholipid hydroperoxide glutathione peroxidase genes accelerates aging in Caenorhabditis elegans. Sakamoto T, et al. Genes Cells, 2014 Oct. PMID 25200408
    5. Molecular basis for antioxidant enzymes in mediating copper detoxification in the nematode Caenorhabditis elegans. Song S, et al. PLoS One, 2014. PMID 25243607, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Glutathione peroxidase
    NP_500242.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2672962..2675015 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067841.5 → NP_500242.2  Glutathione peroxidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500242.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N2X2
      Conserved Domains (1) summary
      cl00388
      Location:39 → 116
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools