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    M04F3.5 IMD domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172093, updated on 9-Dec-2024

    Summary

    Official Symbol
    M04F3.5
    Official Full Name
    IMD domain-containing protein
    Primary source
    WormBase:WBGene00019771
    Locus tag
    CELE_M04F3.5
    See related
    AllianceGenome:WB:WBGene00019771
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin binding activity and phospholipid binding activity. Involved in cell projection assembly and membrane organization. Located in cytoplasmic side of plasma membrane and filopodium. Is expressed in head ganglion; head neurons; and pharynx. Human ortholog(s) of this gene implicated in intellectual developmental disorder with ocular anomalies and distinctive facial features. Orthologous to several human genes including MTSS2 (MTSS I-BAR domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See M04F3.5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (4773819..4788358, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Replication protein A C-terminal domain-containing protein Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 60S ribosomal protein L41 Neighboring gene 60S ribosomal protein L41

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell projection assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in membrane organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    IMD domain-containing protein
    NP_001317862.1
    • Confirmed by transcript evidence
    NP_491448.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4773819..4788358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330926.5NP_001317862.1  IMD domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1C3NSH3
      Conserved Domains (1) summary
      cl12013
      Location:9195
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. NM_059047.8NP_491448.2  IMD domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491448.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95Y95
      Conserved Domains (1) summary
      cl12013
      Location:6192
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature