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    ints-3 SOSS complex subunit A homolog [ Caenorhabditis elegans ]

    Gene ID: 3565441, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ints-3
    Official Full Name
    SOSS complex subunit A homolog
    Primary source
    WormBase:WBGene00022360
    Locus tag
    CELE_Y92H12A.4
    See related
    AllianceGenome:WB:WBGene00022360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be active in cytoplasm. Orthologous to human INTS3 (integrator complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ints-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    17
    Sequence:
    Chromosome: I; NC_003279.8 (1514755..1540926)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Dystrobrevin-1 Neighboring gene tRNA (32-2'-O)-methyltransferase regulator THADA Neighboring gene E3 ubiquitin-protein ligase;HECT-type E3 ubiquitin transferase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PLP-1 binds nematode double-stranded telomeric DNA. Im SH, et al. Mol Cells, 2005 Oct 31. PMID 16267406
    2. Identification of HMG-5 as a double-stranded telomeric DNA-binding protein in the nematode Caenorhabditis elegans. Im SH, et al. FEBS Lett, 2003 Nov 20. PMID 14623111
    3. Disruption of the Caenorhabditis elegans Integrator complex triggers a non-conventional transcriptional mechanism beyond snRNA genes. Gómez-Orte E, et al. PLoS Genet, 2019 Feb. PMID 30807579, Free PMC Article
    4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SOSS complex subunit A homolog
    NP_001293423.1
    • Confirmed by transcript evidence
    NP_001368442.1
    • Confirmed by transcript evidence
    NP_001368443.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1514755..1540926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306494.2 → NP_001293423.1  SOSS complex subunit A homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293423.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RQY9
      Conserved Domains (1) summary
      pfam10189
      Location:249 → 484
      Ints3; Integrator complex subunit 3

    2. NM_001381223.1 → NP_001368442.1  SOSS complex subunit A homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RY35
      Conserved Domains (1) summary
      pfam10189
      Location:85 → 320
      Ints3; Integrator complex subunit 3

    3. NM_001381224.1 → NP_001368443.1  SOSS complex subunit A homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RRX0
      Conserved Domains (1) summary
      pfam10189
      Location:1 → 100
      Ints3; Integrator complex subunit 3

    RNA

    1. NR_131345.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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