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    yars-1 Tyrosine--tRNA ligase [ Caenorhabditis elegans ]

    Gene ID: 173311, updated on 9-Dec-2024

    Summary

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    Official Symbol
    yars-1
    Official Full Name
    Tyrosine--tRNA ligase
    Primary source
    WormBase:WBGene00013677
    Locus tag
    CELE_Y105E8A.19
    See related
    AllianceGenome:WB:WBGene00013677
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity and tyrosine-tRNA ligase activity. Predicted to be involved in tyrosyl-tRNA aminoacylation. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate C. Orthologous to human YARS1 (tyrosyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See yars-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (14476759..14486767, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase Neighboring gene ncRNA Neighboring gene pre-microRNA mir-354 Neighboring gene Small ribosomal subunit protein uS10 Neighboring gene SANT_DAMP1_like domain-containing protein Neighboring gene Methionine--tRNA ligase, mitochondrial Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    2. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
    3. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tyrosine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tyrosyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tyrosine--tRNA ligase
    NP_740947.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14476759..14486767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170951.6 → NP_740947.2  Tyrosine--tRNA ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740947.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED95
      Conserved Domains (2) summary
      TIGR00233
      Location:45 → 359
      trpS; tryptophanyl-tRNA synthetase
      cl00015
      Location:21 → 330
      nt_trans; nucleotidyl transferase superfamily
    Nucleotide Protein
    Heading Accession and Version

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