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    trxr-1 Thioredoxin reductase 1;thioredoxin-disulfide reductase [ Caenorhabditis elegans ]

    Gene ID: 177466, updated on 9-Dec-2024

    Summary

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    Official Symbol
    trxr-1
    Official Full Name
    Thioredoxin reductase 1;thioredoxin-disulfide reductase
    Primary source
    WormBase:WBGene00015553
    Locus tag
    CELE_C06G3.7
    See related
    AllianceGenome:WB:WBGene00015553
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable thioredoxin-disulfide reductase (NADPH) activity. Involved in ecdysis, collagen and cuticulin-based cuticle. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including epithelial cell; intestine; nervous system; pharynx; and vulva. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to several human genes including TXNRD3 (thioredoxin reductase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See trxr-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (7011954..7016586)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Peroxiredoxin Neighboring gene ncRNA Neighboring gene ZZ-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protective effects of the thioredoxin and glutaredoxin systems in dopamine-induced cell death. Arodin L, et al. Free Radic Biol Med, 2014 Aug. PMID 24863694
    2. Selenium species-dependent toxicity, bioavailability and metabolic transformations in Caenorhabditis elegans. Rohn I, et al. Metallomics, 2018 Jun 20. PMID 29770420, Free PMC Article
    3. Toxic-selenium and low-selenium transcriptomes in Caenorhabditis elegans: toxic selenium up-regulates oxidoreductase and down-regulates cuticle-associated genes. Boehler CJ, et al. PLoS One, 2014. PMID 24971995, Free PMC Article
    4. N-γ-(L-Glutamyl)-L-selenomethionine enhances stress resistance and ameliorates aging indicators via the selenoprotein TRXR-1 in Caenorhabditis elegans. Chang CH, et al. Mol Nutr Food Res, 2017 Aug. PMID 28133928
    5. Two thioredoxin reductases, trxr-1 and trxr-2, have differential physiological roles in Caenorhabditis elegans. Li W, et al. Mol Cells, 2012 Aug. PMID 22836943, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Caenorhabditis elegans
      Title: Deletion of thioredoxin reductase and effects of selenite and selenate toxicity in Caenorhabditis elegans.
    2. Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans.
      Title: Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thioredoxin-disulfide reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thioredoxin-disulfide reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thioredoxin-disulfide reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ecdysis, collagen and cuticulin-based cuticle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Thioredoxin reductase 1;thioredoxin-disulfide reductase
    NP_001293761.1
    • Confirmed by transcript evidence
    NP_001294239.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7011954..7016586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307310.3 → NP_001294239.1  Thioredoxin reductase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294239.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17745, Q9N2K1, Q9NJH3
      Conserved Domains (3) summary
      TIGR01438
      Location:173 → 667
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:353 → 426
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:537 → 648
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

    2. NM_001306832.3 → NP_001293761.1  thioredoxin-disulfide reductase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293761.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLN2
      Conserved Domains (1) summary
      TIGR01438
      Location:140 → 634
      TGR; thioredoxin and glutathione reductase selenoprotein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17745.3

    Gene LinkOut

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