cpb-3 Cytoplasmic polyadenylation element-binding protein 3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cpb-3
Official Full Name: Cytoplasmic polyadenylation element-binding protein 3
Primary source: WormBase:WBGene00000772
Locus tag: CELE_B0414.5
See related: AllianceGenome:WB:WBGene00000772
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable mRNA 3'-UTR binding activity; ribosome binding activity; and translation regulator activity, nucleic acid binding. Predicted to be involved in negative regulation of cytoplasmic translation. Predicted to be active in several cellular components, including neuron projection; nucleus; and synapse. Is expressed in PVD; body wall musculature; germ line; intestine; and pharynx. Orthologous to human CPEB1 (cytoplasmic polyadenylation element binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cpb-3 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (5788634..5791752, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CPB-3 and CGH-1 localize to motile particles within dendrites in C. elegans PVD sensory neurons.
Title: CPB-3 and CGH-1 localize to motile particles within dendrites in C. elegans PVD sensory neurons.
CPB-3 expression and degradation during oocyte meiotic progression.
Title: MAPK signaling couples SCF-mediated degradation of translational regulators to oocyte meiotic progression.
Loss of cpb-3 function leads to an increase in physiological germ cell death.
Title: Differential regulation of germ line apoptosis and germ cell differentiation by CPEB family members in C. elegans.
appears to have a conserved role in the early phase of meiosis and in the sperm/oocyte specification, in addition to its reported function during meiotic progression.
Title: C. elegans CPB-3 interacts with DAZ-1 and functions in multiple steps of germline development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0414.5 (e-PCR)
- UniSTS:308385

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IEA Inferred from Electronic Annotation more info
enables mRNA regulatory element binding translation repressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation factor activity, RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Cytoplasmic polyadenylation element-binding protein 3

NP_491680.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5788634..5791752 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059279.8 → NP_491680.2 Cytoplasmic polyadenylation element-binding protein 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491680.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O01835

Conserved Domains (3) summary

cd12444
Location:295 → 412

RRM1_CPEBs; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-1, CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12725
Location:429 → 514

RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

pfam16366
Location:506 → 560

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain