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    mina-1 Messenger RNA-binding inhibitor of apoptosis 1 [ Caenorhabditis elegans ]

    Gene ID: 172786, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mina-1
    Official Full Name
    Messenger RNA-binding inhibitor of apoptosis 1
    Primary source
    WormBase:WBGene00008061
    Locus tag
    CELE_C41G7.3
    See related
    AllianceGenome:WB:WBGene00008061
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables mRNA 3'-UTR binding activity. Acts upstream of or within with a positive effect on negative regulation of apoptotic process and negative regulation of gene expression, epigenetic. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in germ line and oocyte. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mina-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (9517026..9518736, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Kinesin motor domain-containing protein Neighboring gene TspO/MBR family protein Neighboring gene ncRNA Neighboring gene SET domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans. Sendoel A, et al. Cell Death Differ, 2019 Oct. PMID 30728462, Free PMC Article
    2. C30F12.4 influences oogenesis, fat metabolism, and lifespan in C. elegans. Wang L, et al. Protein Cell, 2016 Oct. PMID 27638466, Free PMC Article
    3. A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans. Updike DL, et al. Genetics, 2009 Dec. PMID 19805813, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within_positive_effect negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect negative regulation of gene expression, epigenetic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Messenger RNA-binding inhibitor of apoptosis 1
    NP_492528.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9517026..9518736 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060127.6 → NP_492528.2  Messenger RNA-binding inhibitor of apoptosis 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492528.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93367
      Conserved Domains (1) summary
      smart00322
      Location:259 → 328
      KH; K homology RNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93367.2

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