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    pdpr-1 DAO domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172922, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pdpr-1
    Official Full Name
    DAO domain-containing protein
    Primary source
    WormBase:WBGene00013718
    Locus tag
    CELE_Y106G6H.5
    See related
    AllianceGenome:WB:WBGene00013718
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be active in mitochondrial matrix. Orthologous to human PDPR (pyruvate dehydrogenase phosphatase regulatory subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pdpr-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (10438075..10443563, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Large ribosomal subunit protein eL30 Neighboring gene MADF domain-containing protein Neighboring gene MalT-like TPR region domain-containing protein;TPR_REGION domain-containing protein Neighboring gene Exocyst complex component 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DAO domain-containing protein
    NP_492730.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10438075..10443563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060329.5 → NP_492730.2  DAO domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492730.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U300
      Conserved Domains (6) summary
      COG0404
      Location:439 → 833
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      pfam01266
      Location:23 → 387
      DAO; FAD dependent oxidoreductase
      pfam01571
      Location:449 → 724
      GCV_T; Aminomethyltransferase folate-binding domain
      pfam08669
      Location:733 → 833
      GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
      pfam13450
      Location:28 → 54
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      pfam16350
      Location:394 → 445
      FAO_M; FAD dependent oxidoreductase central domain
    Nucleotide Protein
    Heading Accession and Version

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