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    klc-2 Kinesin light chain [ Caenorhabditis elegans ]

    Gene ID: 178942, updated on 9-Dec-2024

    Summary

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    Official Symbol
    klc-2
    Official Full Name
    Kinesin light chain
    Primary source
    WormBase:WBGene00002215
    Locus tag
    CELE_C18C4.10
    See related
    AllianceGenome:WB:WBGene00002215
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables kinesin binding activity. Involved in several processes, including axon extension; establishment of meiotic spindle localization; and polar body extrusion after meiotic divisions. Located in cytoplasm and nuclear envelope. Part of kinesin I complex. Is expressed in muscle cell; nervous system; and pharynx. Human ortholog(s) of this gene implicated in Alzheimer's disease; SPOAN syndrome; and relapsing-remitting multiple sclerosis. Orthologous to several human genes including KLC1 (kinesin light chain 1) and KLC2 (kinesin light chain 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See klc-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (5576472..5581403, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Proteasome subunit alpha type-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kinesin light chain isoforms in Caenorhabditis elegans. Fan J, et al. J Mol Biol, 1994 Jul 29. PMID 8046755
    2. UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration. Meyerzon M, et al. Development, 2009 Aug. PMID 19605495, Free PMC Article
    3. Sub-cellular distribution of UNC-104(KIF1A) upon binding to adaptors as UNC-16(JIP3), DNC-1(DCTN1/Glued) and SYD-2(Liprin-α) in C. elegans neurons. Hsu CC, et al. Neuroscience, 2011 Mar 10. PMID 21195138
    4. Asymmetric division: a kinesin for spindle positioning. McCarthy EK, et al. Curr Biol, 2005 Aug 9. PMID 16085478
    5. Kinesin-1 and cytoplasmic dynein act sequentially to move the meiotic spindle to the oocyte cortex in Caenorhabditis elegans. Ellefson ML, et al. Mol Biol Cell, 2009 Jun. PMID 19357192, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that accumulation of dynein at poles was kinesin-1 independent and APC dependent, just like dynein driven spindle movements.
      Title: Kinesin-1 and cytoplasmic dynein act sequentially to move the meiotic spindle to the oocyte cortex in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinesin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of meiotic spindle localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of meiotic spindle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear migration along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polar body extrusion after meiotic divisions IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in polar body extrusion after meiotic divisions IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin I complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of kinesin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kinesin light chain
    NP_001023663.1
    • Confirmed by transcript evidence
    NP_001023664.1
    • Confirmed by transcript evidence
    NP_001023665.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5576472..5581403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028494.5 → NP_001023665.1  Kinesin light chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023665.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46822
      Conserved Domains (4) summary
      sd00006
      Location:290 → 318
      TPR; TPR repeat [structural motif]
      pfam13374
      Location:289 → 330
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:286 → 364
      TPR_12; Tetratricopeptide repeat
      cl19252
      Location:92 → 143
      MreC; rod shape-determining protein MreC

    2. NM_001028492.5 → NP_001023663.1  Kinesin light chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023663.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46822
      Conserved Domains (4) summary
      sd00006
      Location:311 → 339
      TPR; TPR repeat [structural motif]
      pfam13374
      Location:310 → 351
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:307 → 385
      TPR_12; Tetratricopeptide repeat
      cl19252
      Location:113 → 164
      MreC; rod shape-determining protein MreC

    3. NM_001028493.7 → NP_001023664.1  Kinesin light chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023664.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46822, Q18088, Q6BEW4, Q8I7M2, Q8TA80, Q95QV1
      Conserved Domains (4) summary
      sd00006
      Location:290 → 318
      TPR; TPR repeat [structural motif]
      pfam13374
      Location:289 → 330
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:286 → 364
      TPR_12; Tetratricopeptide repeat
      cl19252
      Location:92 → 143
      MreC; rod shape-determining protein MreC
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46822.2

    Gene LinkOut

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