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    dph-2 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 [ Caenorhabditis elegans ]

    Gene ID: 174649, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dph-2
    Official Full Name
    2-(3-amino-3-carboxypropyl)histidine synthase subunit 2
    Primary source
    WormBase:WBGene00007488
    Locus tag
    CELE_C09G5.2
    See related
    AllianceGenome:WB:WBGene00007488
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to contribute to 2-(3-amino-3-carboxypropyl)histidine synthase activity. Predicted to be involved in protein histidyl modification to diphthamide. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in diphthamide deficiency syndrome 2. Orthologous to human DPH2 (diphthamide biosynthesis 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dph-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (10702510..10714297, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene RRM domain-containing protein Neighboring gene ncRNA Neighboring gene putative gamma-butyrobetaine dioxygenase Neighboring gene Glycine receptor subunit beta-type 4 Neighboring gene Putative cuticle collagen 79 Neighboring gene Cuticle collagen 39 Neighboring gene Putative cuticle collagen 80 Neighboring gene Cuticle collagen bli-1 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Slow Recovery from Inbreeding Depression Generated by the Complex Genetic Architecture of Segregating Deleterious Mutations. Adams PE, et al. Mol Biol Evol, 2022 Jan 7. PMID 34791426, Free PMC Article
    2. Nanoscale patterning of collagens in C. elegans apical extracellular matrix. Adams JRG, et al. Nat Commun, 2023 Nov 18. PMID 37980413, Free PMC Article
    3. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 2-(3-amino-3-carboxypropyl)histidine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to 2-(3-amino-3-carboxypropyl)histidine synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein histidyl modification to diphthamide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein histidyl modification to diphthamide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein histidyl modification to diphthamide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    part_of protein-containing complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    2-(3-amino-3-carboxypropyl)histidine synthase subunit 2
    NP_001254257.1
    • Confirmed by transcript evidence
    NP_001254258.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10702510..10714297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267328.3 → NP_001254257.1  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254257.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F5GU80, Q09454
      Conserved Domains (1) summary
      cl19374
      Location:6 → 476
      Diphthamide_syn; Putative diphthamide synthesis protein

    2. NM_001267329.3 → NP_001254258.1  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254258.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09454
      Conserved Domains (1) summary
      cl19374
      Location:1 → 169
      Diphthamide_syn; Putative diphthamide synthesis protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09454.2

    Gene LinkOut

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