rnf-121 E3 ubiquitin ligase rnf-121 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rnf-121
Official Full Name: E3 ubiquitin ligase rnf-121
Primary source: WormBase:WBGene00007626
Locus tag: CELE_C16C10.5
See related: AllianceGenome:WB:WBGene00007626
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ubiquitin protein ligase activity. Involved in ERAD pathway; PERK-mediated unfolded protein response; and inductive cell migration. Located in Golgi membrane and sarcoplasmic reticulum membrane. Is expressed in body wall musculature; gonad; hypodermis; and vulva. Orthologous to human RNF121 (ring finger protein 121) and RNF175 (ring finger protein 175). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rnf-121 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (4168777..4170953, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings identify RNF-121 as an ER-anchored ubiquitin ligase that plays a specific role in the ERAD pathway by linking it to the regulation of the cell adhesion integrin receptors through PAT-3, an RNF-121 substrate.
Title: RNF-121 is an endoplasmic reticulum-membrane E3 ubiquitin ligase involved in the regulation of beta-integrin.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C16C10.5 (e-PCR)
- UniSTS:307257

C16C10.4 (e-PCR)
- UniSTS:320462

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in PERK-mediated unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inductive cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in inductive cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin ligase rnf-121

NP_497832.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4168777..4170953 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065431.6 → NP_497832.2 E3 ubiquitin ligase rnf-121 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497832.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09251

Conserved Domains (2) summary

cd16475
Location:221 → 286

RING-H2_RNF121-like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins

cl28910
Location:53 → 187

MFS; Major Facilitator Superfamily