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    gpa-13 G-protein alpha subunit;Guanine nucleotide-binding protein alpha-13 subunit [ Caenorhabditis elegans ]

    Gene ID: 179746, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gpa-13
    Official Full Name
    G-protein alpha subunit;Guanine nucleotide-binding protein alpha-13 subunit
    Primary source
    WormBase:WBGene00001675
    Locus tag
    CELE_F18E2.5
    See related
    AllianceGenome:WB:WBGene00001675
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables G-protein alpha-subunit binding activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Located in axon; neuronal cell body; and non-motile cilium. Is expressed in neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gpa-13 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (12752603..12754939, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Activin_recp domain-containing protein Neighboring gene Serpentine Receptor, class Z Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Purple acid phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Uncoordinated (UNC)119: coordinating the trafficking of myristoylated proteins. Constantine R, et al. Vision Res, 2012 Dec 15. PMID 23000199, Free PMC Article
    2. A network of stimulatory and inhibitory Galpha-subunits regulates olfaction in Caenorhabditis elegans. Lans H, et al. Genetics, 2004 Aug. PMID 15342507, Free PMC Article
    3. UNC119 is required for G protein trafficking in sensory neurons. Zhang H, et al. Nat Neurosci, 2011 Jun 5. PMID 21642972, Free PMC Article
    4. High nucleotide divergence in developmental regulatory genes contrasts with the structural elements of olfactory pathways in caenorhabditis. Jovelin R, et al. Genetics, 2009 Apr. PMID 19001295, Free PMC Article
    5. unc-42 regulates the expression of ASH terminal fate markers. Wood J, et al. MicroPubl Biol, 2019 May 15. PMID 32550468, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein alpha-subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G-protein alpha subunit;Guanine nucleotide-binding protein alpha-13 subunit
    NP_001256450.1
    • Confirmed by transcript evidence
    NP_001256451.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12752603..12754939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269522.3 → NP_001256451.1  G-protein alpha subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256451.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC80
      Conserved Domains (3) summary
      cd00066
      Location:90 → 401
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:70 → 397
      G_alpha; G protein alpha subunit
      pfam10210
      Location:13 → 54
      MRP-S32; Mitochondrial 28S ribosomal protein S32

    2. NM_001269521.2 → NP_001256450.1  Guanine nucleotide-binding protein alpha-13 subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256450.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9BIG3, Q9XTB2
      Conserved Domains (2) summary
      cd00066
      Location:36 → 347
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:16 → 343
      G_alpha; G protein alpha subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XTB2.2

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