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    gap-1 C2 domain-containing protein;GTPase Activating Protein family;Ras GTPase-activating protein gap-1 [ Caenorhabditis elegans ]

    Gene ID: 180530, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gap-1
    Official Full Name
    C2 domain-containing protein;GTPase Activating Protein family;Ras GTPase-activating protein gap-1
    Primary source
    WormBase:WBGene00001515
    Locus tag
    CELE_T24C12.2
    See related
    AllianceGenome:WB:WBGene00001515
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity. Involved in chemosensory behavior; learning or memory; and negative regulation of Ras protein signal transduction. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Noonan syndrome. Orthologous to several human genes including RASA3 (RAS p21 protein activator 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gap-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    19
    Sequence:
    Chromosome: X; NC_003284.9 (2180888..2196512)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Pigment dispersing factor homolog pdf-2 Neighboring gene ZP domain-containing protein Neighboring gene RDD domain-containing protein Neighboring gene Carbohydrate kinase PfkB domain-containing protein Neighboring gene Tetraspanin family protein Neighboring gene ShKT domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tissue-specific functions of the Caenorhabditis elegans p120 Ras GTPase activating protein GAP-3. Stetak A, et al. Dev Biol, 2008 Nov 15. PMID 18805410
    2. Distinct roles of the RasGAP family proteins in C. elegans associative learning and memory. Gyurkó MD, et al. Sci Rep, 2015 Oct 15. PMID 26469632, Free PMC Article
    3. Requirements of multiple domains of SLI-1, a Caenorhabditis elegans homologue of c-Cbl, and an inhibitory tyrosine in LET-23 in regulating vulval differentiation. Yoon CH, et al. Mol Biol Cell, 2000 Nov. PMID 11071924, Free PMC Article
    4. Cryptic quantitative evolution of the vulva intercellular signaling network in Caenorhabditis. Félix MA. Curr Biol, 2007 Jan 23. PMID 17240335
    5. Activation of Ras and the mitogen-activated protein kinase pathway promotes protein degradation in muscle cells of Caenorhabditis elegans. Szewczyk NJ, et al. Mol Cell Biol, 2002 Jun. PMID 12024031, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in associative learning IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in associative learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in long-term memory IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of Ras protein signal transduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in short-term memory IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C2 domain-containing protein;GTPase Activating Protein family;Ras GTPase-activating protein gap-1
    NP_001417861.1
    • Product from WormBase gene class gap;
      Confirmed by transcript evidence
    NP_508403.2
    • Partially confirmed by transcript evidence
    NP_508404.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2180888..2196512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001430923.2 → NP_001417861.1  GTPase Activating Protein family [Caenorhabditis elegans]

      Status: REVIEWED

    2. NM_076002.4 → NP_508403.2  C2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508403.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20558

    3. NM_076003.1 → NP_508404.1  Ras GTPase-activating protein gap-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508404.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22720
      Conserved Domains (4) summary
      cd05128
      Location:134 → 401
      RasGAP_GAP1_like; Ras-GTPase Activating Domain of GAP1 and similar proteins
      smart00233
      Location:424 → 504
      PH; Pleckstrin homology domain
      smart00323
      Location:119 → 459
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam00169
      Location:434 → 504
      PH; PH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22720.1

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