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    F10G8.8 PH domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172870, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F10G8.8
    Official Full Name
    PH domain-containing protein
    Primary source
    WormBase:WBGene00008666
    Locus tag
    CELE_F10G8.8
    See related
    AllianceGenome:WB:WBGene00008666
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity. Predicted to be active in actin cytoskeleton. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 28. Orthologous to several human genes including MPRIP (myosin phosphatase Rho interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F10G8.8 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    15
    Sequence:
    Chromosome: I; NC_003279.8 (10050685..10062026, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ERCC1-like central domain-containing protein Neighboring gene ncRNA Neighboring gene Cytosolic Fe-S cluster assembly factor NUBP1 homolog Neighboring gene beta-ketoacyl-[acyl-carrier-protein] synthase I Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KIN-4/MAST kinase promotes PTEN-mediated longevity of Caenorhabditis elegans via binding through a PDZ domain. An SWA, et al. Aging Cell, 2019 Jun. PMID 30773781, Free PMC Article
    2. Protein interaction mapping in C. elegans using proteins involved in vulval development. Walhout AJ, et al. Science, 2000 Jan 7. PMID 10615043
    3. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
    4. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
    5. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PH domain-containing protein
    NP_001122450.1
    • Confirmed by transcript evidence
    NP_492655.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10050685..10062026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001128978.4 → NP_001122450.1  PH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122450.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE23
      Conserved Domains (4) summary
      cd01236
      Location:13 → 154
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:292 → 394
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:292 → 383
      PH; PH domain
      cl00459
      Location:511 → 674
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    2. NM_060254.7 → NP_492655.2  PH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492655.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG76
      Conserved Domains (4) summary
      cd01236
      Location:13 → 154
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:292 → 394
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:292 → 383
      PH; PH domain
      cl00459
      Location:511 → 674
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    Nucleotide Protein
    Heading Accession and Version

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