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    gspd-1 Glucose-6-phosphate 1-dehydrogenase [ Caenorhabditis elegans ]

    Gene ID: 178046, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gspd-1
    Official Full Name
    Glucose-6-phosphate 1-dehydrogenase
    Primary source
    WormBase:WBGene00007108
    Locus tag
    CELE_B0035.5
    See related
    AllianceGenome:WB:WBGene00007108
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glucose-6-phosphate dehydrogenase activity. Predicted to be involved in glucose metabolic process and pentose-phosphate shunt, oxidative branch. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gspd-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (11317419..11319951)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene putative prefoldin subunit 4 Neighboring gene Mitochondrial cytochrome c oxidase subunit VIc/VIIs domain-containing protein Neighboring gene Protein edg-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modeling human glucose-6-phosphate dehydrogenase mutations using C. elegans GSPD-1. Loges LN, et al. MicroPubl Biol, 2021. PMID 34532700, Free PMC Article
    2. tert-Butyl Hydroperoxide (tBHP)-Induced Lipid Peroxidation and Embryonic Defects Resemble Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in C. elegans. Yang HC, et al. Int J Mol Sci, 2020 Nov 18. PMID 33217954, Free PMC Article
    3. The impact of glucose on mitochondria and life span is determined by the integrity of proline catabolism in Caenorhabditis elegans. Feng X, et al. J Biol Chem, 2023 Feb. PMID 36626986, Free PMC Article
    4. Impaired embryonic development in glucose-6-phosphate dehydrogenase-deficient Caenorhabditis elegans due to abnormal redox homeostasis induced activation of calcium-independent phospholipase and alteration of glycerophospholipid metabolism. Chen TL, et al. Cell Death Dis, 2017 Jan 12. PMID 28079896, Free PMC Article
    5. Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis. Leopold JA, et al. J Biol Chem, 2003 Aug 22. PMID 12777375

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. tert-Butyl Hydroperoxide (tBHP)-Induced Lipid Peroxidation and Embryonic Defects Resemble Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in C. elegans.
      Title: tert-Butyl Hydroperoxide (tBHP)-Induced Lipid Peroxidation and Embryonic Defects Resemble Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in C. elegans.
    2. Abnormal glycerophospholipid metabolism leading to defective embryonic development could be attributed to the increased activity of calcium-independent phospholipase A2 (iPLA) in G6PD-deficient embryos. This notion is further supported by the fact that the suppression of multiple iPLAs by genetic manipulation partially rescued the embryonic defects in G6PD-deficient embryos.
      Title: Impaired embryonic development in glucose-6-phosphate dehydrogenase-deficient Caenorhabditis elegans due to abnormal redox homeostasis induced activation of calcium-independent phospholipase and alteration of glycerophospholipid metabolism.
    3. role in modulating vascular endothelial growth factor-mediated angiogenesis
      Title: Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADP metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glucose 6-phosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt, oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Glucose-6-phosphate 1-dehydrogenase
    NP_502129.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11317419..11319951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069728.7 → NP_502129.1  Glucose-6-phosphate 1-dehydrogenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502129.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27464
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27464.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.