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    pmp-3 ATP-binding cassette sub-family D member 4 [ Caenorhabditis elegans ]

    Gene ID: 179968, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pmp-3
    Official Full Name
    ATP-binding cassette sub-family D member 4
    Primary source
    WormBase:WBGene00004060
    Locus tag
    CELE_C54G10.3
    See related
    AllianceGenome:WB:WBGene00004060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and long-chain fatty acid transmembrane transporter activity. Predicted to be involved in fatty acid catabolic process; long-chain fatty acid import into peroxisome; and peroxisome organization. Predicted to be located in membrane. Predicted to be active in peroxisomal membrane. Orthologous to human ABCD4 (ATP binding cassette subfamily D member 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pmp-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (14646739..14653493)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Replication factor C subunit 1 Neighboring gene Mitochondrial carnitine/acylcarnitine carrier protein CACL Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class H

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Non-Ionic Surfactants Antagonize Toxicity of Potential Phenolic Endocrine-Disrupting Chemicals, Including Triclosan in Caenorhabditis elegans. Alfhili MA, et al. Mol Cells, 2018 Dec 31. PMID 30453732, Free PMC Article
    2. A Caenorhabditis elegans model of adenylosuccinate lyase deficiency reveals neuromuscular and reproductive phenotypes of distinct etiology. Fenton AR, et al. Mol Genet Metab, 2023 Nov. PMID 37607437, Free PMC Article
    3. Role of NH2-terminal hydrophobic motif in the subcellular localization of ATP-binding cassette protein subfamily D: common features in eukaryotic organisms. Lee A, et al. Biochem Biophys Res Commun, 2014 Oct 24. PMID 25301552
    4. An autoregulation loop in fust-1 for circular RNA regulation in Caenorhabditis elegans. Cao D. Genetics, 2021 Nov 5. PMID 34740247, Free PMC Article
    5. Evaluation and normalization of a set of reliable reference genes for quantitative sgk-1 gene expression analysis in Caenorhabditis elegans-focused cancer research. Özdemir ÖÜ, et al. Nucleosides Nucleotides Nucleic Acids, 2024 Feb 15. PMID 38359339

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid import into peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peroxisome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very long-chain fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family D member 4
    NP_001256607.1
    • Confirmed by transcript evidence
    NP_001256608.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14646739..14653493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269678.3 → NP_001256607.1  ATP-binding cassette sub-family D member 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256607.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F5GUC6
      Conserved Domains (3) summary
      cd03223
      Location:450 → 662
      ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
      COG4178
      Location:37 → 655
      YddA; ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]
      pfam06472
      Location:34 → 314
      ABC_membrane_2; ABC transporter transmembrane region 2

    2. NM_001269679.3 → NP_001256608.1  ATP-binding cassette sub-family D member 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256608.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18843
      Conserved Domains (3) summary
      cd03223
      Location:422 → 634
      ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
      COG4178
      Location:9 → 627
      YddA; ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]
      pfam06472
      Location:6 → 286
      ABC_membrane_2; ABC transporter transmembrane region 2
    Nucleotide Protein
    Heading Accession and Version

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