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    sqt-1 Cuticle collagen sqt-1 [ Caenorhabditis elegans ]

    Gene ID: 174731, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sqt-1
    Official Full Name
    Cuticle collagen sqt-1
    Primary source
    WormBase:WBGene00005016
    Locus tag
    CELE_B0491.2
    See related
    AllianceGenome:WB:WBGene00005016
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    A structural constituent of collagen and cuticulin-based cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Predicted to be part of collagen trimer. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sqt-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003280.10 (11336693..11337837, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene tRNA-Ala Neighboring gene ncRNA Neighboring gene tRNA-Ala Neighboring gene Regulator of microtubule dynamics protein 1 Neighboring gene Neurotransmitter-gated ion-channel ligand-binding domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Efficient Transgenesis in Caenorhabditis elegans Using Flp Recombinase-Mediated Cassette Exchange. Nonet ML. Genetics, 2020 Aug. PMID 32513816, Free PMC Article
    2. Proteolytic processing of Caenorhabditis elegans SQT-1 cuticle collagen is inhibited in right roller mutants whereas cross-linking is inhibited in left roller mutants. Yang J, et al. J Biol Chem, 1999 Nov 12. PMID 10551833
    3. The sqt-1 gene of C. elegans encodes a collagen critical for organismal morphogenesis. Kramer JM, et al. Cell, 1988 Nov 18. PMID 3180220
    4. CRISPR/Cas9 Genome Editing in Caenorhabditis elegans: Evaluation of Templates for Homology-Mediated Repair and Knock-Ins by Homology-Independent DNA Repair. Katic I, et al. G3 (Bethesda), 2015 Jun 3. PMID 26044730, Free PMC Article
    5. The Caenorhabditis elegans rol-6 gene, which interacts with the sqt-1 collagen gene to determine organismal morphology, encodes a collagen. Kramer JM, et al. Mol Cell Biol, 1990 May. PMID 1970117, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables structural constituent of cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen and cuticulin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cuticle collagen sqt-1
    NP_001369874.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11336693..11337837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383951.2 → NP_001369874.1  Cuticle collagen sqt-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P12114, Q17509
      Conserved Domains (3) summary
      smart01088
      Location:8 → 57
      Col_cuticle_N; Nematode cuticle collagen N-terminal domain
      PHA03169
      Location:132 → 293
      PHA03169; hypothetical protein; Provisional
      pfam01391
      Location:170 → 225
      Collagen; Collagen triple helix repeat (20 copies)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12114.2

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