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    rle-1 Regulation of longevity by E3 ubiquitin-protein ligase [ Caenorhabditis elegans ]

    Gene ID: 176525, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rle-1
    Official Full Name
    Regulation of longevity by E3 ubiquitin-protein ligase
    Primary source
    WormBase:WBGene00010923
    Locus tag
    CELE_M142.6
    See related
    AllianceGenome:WB:WBGene00010923
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ubiquitin-protein transferase activity. Involved in determination of adult lifespan; response to heat; and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasmic stress granule. Is expressed in several structures, including hypodermis; intestine; and reproductive system. Orthologous to several human genes including RC3H1 (ring finger and CCCH-type domains 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rle-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (10936244..10947330)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene AD domain-containing protein Neighboring gene Protein-lysine N-methyltransferase M142.8 Neighboring gene ncRNA Neighboring gene STE20-related kinase adapter protein strd-1 Neighboring gene Zwei Ig domain protein zig-5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination. Li W, et al. Dev Cell, 2007 Feb. PMID 17276341
    2. Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses. Maruyama T, et al. Sci Signal, 2014 Jan 21. PMID 24448648
    3. The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs. Athanasopoulos V, et al. FEBS J, 2010 May. PMID 20412057
    4. The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity. Heimbucher T, et al. Cell Metab, 2015 Jul 7. PMID 26154057, Free PMC Article
    5. The silencing of ets-4 mRNA relies on the functional cooperation between REGE-1/Regnase-1 and RLE-1/Roquin-1. Sobańska D, et al. Nucleic Acids Res, 2022 Aug 12. PMID 35819231, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RLE-1 is an E3 ubiquitin ligase of DAF-16 that regulates C. elegans aging.
      Title: RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA stem-loop binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Regulation of longevity by E3 ubiquitin-protein ligase
    NP_001366782.1
    • Confirmed by transcript evidence
    NP_001367283.1
    • Confirmed by transcript evidence
    NP_001367296.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10936244..10947330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001379917.1 → NP_001367296.1  Regulation of longevity by E3 ubiquitin-protein ligase [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      pfam18386
      Location:266 → 321
      ROQ_II; Roquin II domain
      cl17238
      Location:13 → 56
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. NM_001379916.1 → NP_001366782.1  Regulation of longevity by E3 ubiquitin-protein ligase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F5GUI8, G5EDG1, O45962, Q93898
      Conserved Domains (2) summary
      pfam18386
      Location:266 → 321
      ROQ_II; Roquin II domain
      cl17238
      Location:13 → 56
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. NM_001379918.1 → NP_001367283.1  Regulation of longevity by E3 ubiquitin-protein ligase [Caenorhabditis elegans]

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O45962.4

    Gene LinkOut

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