U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    pes-7 Calponin-homology (CH) domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173294, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    pes-7
    Official Full Name
    Calponin-homology (CH) domain-containing protein
    Primary source
    WormBase:WBGene00003980
    Locus tag
    CELE_F09C3.1
    See related
    AllianceGenome:WB:WBGene00003980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity; actin filament binding activity; and calmodulin binding activity. Predicted to be involved in mitotic actomyosin contractile ring assembly actin filament organization. Predicted to be active in cell cortex. Is expressed in several structures, including hypodermis; intestine; nervous system; reproductive system; and tail. Orthologous to human IQGAP1 (IQ motif containing GTPase activating protein 1); IQGAP2 (IQ motif containing GTPase activating protein 2); and IQGAP3 (IQ motif containing GTPase activating protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See pes-7 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (14263297..14271321)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene CW domain-containing protein Neighboring gene Secreted protein Neighboring gene Phosphoglycolate phosphatase Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Glia Promote Synaptogenesis through an IQGAP PES-7 in C. elegans. Dong X, et al. Cell Rep, 2020 Feb 25. PMID 32101740
    2. Molecular markers of differentiation in Caenorhabditis elegans obtained by promoter trapping. Young JM, et al. Dev Dyn, 1993 Feb. PMID 8364222
    3. Sticky worms: adhesion complexes in C. elegans. Cox EA, et al. J Cell Sci, 2004 Apr 15. PMID 15090594
    4. Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission. Locke CJ, et al. Genetics, 2009 Dec. PMID 19797046, Free PMC Article
    5. In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics. Lacroix B, et al. Dev Cell, 2014 Apr 28. PMID 24780738, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glia Promote Synaptogenesis through an IQGAP PES-7 in C. elegans.
      Title: Glia Promote Synaptogenesis through an IQGAP PES-7 in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic actomyosin contractile ring assembly actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Calponin-homology (CH) domain-containing protein
    NP_493492.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14263297..14271321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061091.6 → NP_493492.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493492.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17772
      Conserved Domains (4) summary
      cd12206
      Location:790 → 1147
      RasGAP_IQGAP_related; Ras-GTPase Activating Domain of proteins related to IQGAPs
      pfam00307
      Location:46 → 157
      CH; Calponin homology (CH) domain
      pfam03836
      Location:1184 → 1313
      RasGAP_C; RasGAP C-terminus
      cl21455
      Location:363 → 474
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.