B0035.3 Macro domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: B0035.3
Official Full Name: Macro domain-containing protein
Primary source: WormBase:WBGene00007106
Locus tag: CELE_B0035.3
See related: AllianceGenome:WB:WBGene00007106
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ADP-ribosylglutamate hydrolase activity. Predicted to be involved in DNA damage response and purine nucleoside metabolic process. Predicted to be active in nucleoplasm. Orthologous to several human genes including MACROD2 (mono-ADP ribosylhydrolase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See B0035.3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 4

Sequence:: Chromosome: IV; NC_003282.8 (11314078..11314998, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0035.4 (e-PCR)
- UniSTS:320827

STS4-9 (e-PCR)
- UniSTS:242256

B0035.3 (e-PCR)
- UniSTS:320438

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ADP-ribosylglutamate hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine nucleoside metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Macro domain-containing protein

NP_502127.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

11314078..11314998 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069726.7 → NP_502127.1 Macro domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502127.1

Status: REVIEWED

UniProtKB/TrEMBL

Q17432

Conserved Domains (1) summary

PRK00431
Location:25 → 190

PRK00431; ADP-ribose-binding protein