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    ifb-2 Intermediate filament protein ifb-2 [ Caenorhabditis elegans ]

    Gene ID: 173973, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ifb-2
    Official Full Name
    Intermediate filament protein ifb-2
    Primary source
    WormBase:WBGene00002054
    Locus tag
    CELE_F10C1.7
    See related
    AllianceGenome:WB:WBGene00002054
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including heterochromatin formation; nucleus organization; and protein localization to nuclear envelope. Located in apical cortex; cell junction; and terminal web. Is expressed in intestine. Human ortholog(s) of this gene implicated in partial lipodystrophy; primary autosomal recessive microcephaly; and progressive myoclonus epilepsy 9. Orthologous to human LMNB2 (lamin B2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ifb-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    11
    Sequence:
    Chromosome: II; NC_003280.10 (5750188..5754140)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene LTD domain-containing protein Neighboring gene Variable outer membrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans proteome response to two protective Pseudomonas symbionts. Pees B, et al. mBio, 2024 Apr 10. PMID 38411078, Free PMC Article
    2. Non-lytic, actin-based exit of intracellular parasites from C. elegans intestinal cells. Estes KA, et al. PLoS Pathog, 2011 Sep. PMID 21949650, Free PMC Article
    3. Maintenance of the intestinal tube in Caenorhabditis elegans: the role of the intermediate filament protein IFC-2. Hüsken K, et al. Differentiation, 2008 Oct. PMID 18452552
    4. The apical disposition of the Caenorhabditis elegans intestinal terminal web is maintained by LET-413. Bossinger O, et al. Dev Biol, 2004 Apr 15. PMID 15063180
    5. The novel intestinal filament organizer IFO-1 contributes to epithelial integrity in concert with ERM-1 and DLG-1. Carberry K, et al. Development, 2012 May. PMID 22510987, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear envelope organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear pore localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear lamina IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in terminal web IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Intermediate filament protein ifb-2
    NP_001293525.1
    • Partially confirmed by transcript evidence
    NP_495133.1
    • Confirmed by transcript evidence
    NP_495134.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5750188..5754140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062733.7 → NP_495134.1  Intermediate filament protein ifb-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495134.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19286
      Conserved Domains (2) summary
      pfam00038
      Location:39 → 387
      Filament; Intermediate filament protein
      pfam00932
      Location:411 → 517
      LTD; Lamin Tail Domain

    2. NM_062732.6 → NP_495133.1  Intermediate filament protein ifb-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495133.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19286, Q21064, Q95QM2
      Conserved Domains (2) summary
      pfam00038
      Location:39 → 387
      Filament; Intermediate filament protein
      pfam00932
      Location:428 → 534
      LTD; Lamin Tail Domain

    3. NM_001306596.3 → NP_001293525.1  Intermediate filament protein ifb-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293525.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M1Z854
      Conserved Domains (3) summary
      pfam00038
      Location:39 → 387
      Filament; Intermediate filament protein
      pfam00932
      Location:462 → 568
      LTD; Lamin Tail Domain
      cl21478
      Location:153 → 307
      ATP-synt_B; ATP synthase B/B' CF(0)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19286.1

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