eya-1 Eyes absent homolog 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: eya-1
Official Full Name: Eyes absent homolog 1
Primary source: WormBase:WBGene00001377
Locus tag: CELE_C49A1.4
See related: AllianceGenome:WB:WBGene00001377
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein tyrosine phosphatase activity and transcription coactivator activity. Involved in several processes, including egg-laying behavior; positive regulation of cellular response to heat; and regulation of apoptotic process. Located in nucleus. Is expressed in several structures, including body wall musculature; intestine; and pharynx. Human ortholog(s) of this gene implicated in auditory system disease (multiple); branchiootorenal syndrome (multiple); congestive heart failure; and dilated cardiomyopathy (multiple). Orthologous to several human genes including EYA1 (EYA transcriptional coactivator and phosphatase 1); EYA2 (EYA transcriptional coactivator and phosphatase 2); and EYA3 (EYA transcriptional coactivator and phosphatase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See eya-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (14220693..14231360, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EYA-1 is required for genomic integrity independent of H2AX signalling in Caenorhabditis elegans.
Title: EYA-1 is required for genomic integrity independent of H2AX signalling in Caenorhabditis elegans.
eya-1 and pax-6/Pax6 mutants showed a strong genetic interaction for larval viability and embryonic anterior morphogenesis.
Title: The C. elegans eyes absent ortholog EYA-1 is required for tissue differentiation and plays partially redundant roles with PAX-6.
EYA-1 is required for stress resistance of worms, and it might act downstream of daf-16 to regulate expression of stress resistance-associated genes.
Title: Caenorhabditis elegans eyes absent ortholog EYA-1 is required for stress resistance.
Data show that loss of ceh-34 or eya-1 function causes survival of the M4 sister cell, which normally undergoes programmed cell death.
Title: Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans.
Six homeodomain protein CEH-34 and its cofactor Eyes Absent, EYA-1, function synergistically to promote the non-muscle fate in cells also competent to form muscles.
Title: A conserved Six-Eya cassette acts downstream of Wnt signaling to direct non-myogenic versus myogenic fates in the C. elegans postembryonic mesoderm.
eya-1 was expressed in the nuclei of a subset of anterior cells, starting from the morphogenesis stage in embryogenesis; eya-1 and pax-6/Pax6 mutants showed a strong genetic interaction for larval viability and embryonic anterior morphogenesis.
Title: The C. elegans eyes absent ortholog EYA-1 is required for tissue differentiation and plays partially redundant roles with PAX-6.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C49A1.4 (e-PCR)
- UniSTS:305813

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IBA Inferred from Biological aspect of Ancestor more info
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process involved in development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Eyes absent homolog 1

NP_001021055.1

Confirmed by transcript evidence

NP_001367120.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

14220693..14231360 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001025884.6 → NP_001021055.1 Eyes absent homolog 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021055.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O17670, Q564S5

Conserved Domains (1) summary

cd02601
Location:230 → 503

HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
NM_001381258.2 → NP_001367120.1 Eyes absent homolog 1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd02601
Location:196 → 469

HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains