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    gcy-32 Soluble guanylate cyclase gcy-32 [ Caenorhabditis elegans ]

    Gene ID: 179887, updated on 4-Jan-2025

    Summary

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    Official Symbol
    gcy-32
    Official Full Name
    Soluble guanylate cyclase gcy-32
    Primary source
    WormBase:WBGene00001552
    Locus tag
    CELE_C06B3.8
    See related
    AllianceGenome:WB:WBGene00001552
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanylate cyclase activity. Predicted to be involved in cGMP-mediated signaling and response to oxygen levels. Predicted to be located in cytoplasm. Predicted to be part of guanylate cyclase complex, soluble. Is expressed in AQR; PQR; URXL; and URXR. Orthologous to human GUCY1B2 (guanylate cyclase 1 soluble subunit beta 2 (pseudogene)). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See gcy-32 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (13912080..13915490, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF3444 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Seven TM Receptor Neighboring gene Seven TM Receptor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antagonistic pathways in neurons exposed to body fluid regulate social feeding in Caenorhabditis elegans. Coates JC, et al. Nature, 2002 Oct 31. PMID 12410311
    2. Experience-dependent modulation of C. elegans behavior by ambient oxygen. Cheung BH, et al. Curr Biol, 2005 May 24. PMID 15916947
    3. Protein interaction surface of the POU transcription factor UNC-86 selectively used in touch neurons. Röhrig S, et al. EMBO J, 2000 Jul 17. PMID 10899123, Free PMC Article
    4. Nematode memory: now, where was I? Rankin CH. Curr Biol, 2005 May 24. PMID 15916936
    5. Soluble guanylyl cyclases in Caenorhabditis elegans: NO is not the answer. Morton DB, et al. Curr Biol, 1999 Jul 29-Aug 12. PMID 10469574

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxygen levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of guanylate cyclase complex, soluble IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Soluble guanylate cyclase gcy-32
    NP_506452.5
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13912080..13915490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074051.6 → NP_506452.5  Soluble guanylate cyclase gcy-32 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506452.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17707, Q6DNF7, Q9BI80
      Conserved Domains (4) summary
      smart00044
      Location:419 → 608
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:452 → 627
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:3 → 167
      HNOB; Haem-NO-binding
      pfam07701
      Location:226 → 440
      HNOBA; Heme NO binding associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DNF7.1

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