ace-2 Carboxylic ester hydrolase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ace-2
Official Full Name: Carboxylic ester hydrolase
Primary source: WormBase:WBGene00000036
Locus tag: CELE_Y44E3A.2
See related: AllianceGenome:WB:WBGene00000036
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables acetylcholinesterase activity and protein homodimerization activity. Involved in acetylcholine catabolic process; cholinergic synaptic transmission; and regulation of locomotion. Predicted to be located in synapse and synaptic cleft. Predicted to be active in extracellular space and plasma membrane. Is expressed in several structures, including neurons; pm5; somatic nervous system; and tail hypodermis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease (multiple); epilepsy; and inherited metabolic disorder (multiple). Orthologous to human BCHE (butyrylcholinesterase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ace-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (3301368..3307935, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ACE-1 is an amphiphilic tetramer associated with a hydrophobic non-catalytic subunit, analogous to vertebrate T enzymes, whereas ACE-2 and ACE-3 are glycosylphosphatidylinositol-linked amphiphilic dimers
Title: Nematode acetylcholinesterases are encoded by multiple genes and perform non-overlapping functions.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y44E3A.2 (e-PCR)
- UniSTS:318871

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acetylcholinesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholinesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholinesterase activity	IEA Inferred from Electronic Annotation more info
enables acetylcholinesterase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables cholinesterase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in acetylcholine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acetylcholine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in acetylcholine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in acetylcholine catabolic process in synaptic cleft	IC Inferred by Curator more info	PubMed
involved_in choline metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, cholinergic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic cleft	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Carboxylic ester hydrolase

NP_491141.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

3301368..3307935 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058740.6 → NP_491141.1 Carboxylic ester hydrolase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491141.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EDV9

Conserved Domains (2) summary

COG0657
Location:135 → 233

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam00135
Location:33 → 546

COesterase; Carboxylesterase family