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    tyra-3 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 187427, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tyra-3
    Official Full Name
    G-protein coupled receptors family 1 profile domain-containing protein
    Primary source
    WormBase:WBGene00006475
    Locus tag
    CELE_M03F4.3
    See related
    AllianceGenome:WB:WBGene00006475
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable neurotransmitter receptor activity and octopamine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Predicted to be located in membrane and synapse. Predicted to be active in dendrite and plasma membrane. Is expressed in intestine; nervous system; and reproductive system. Used to study Parkinson's disease. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tyra-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (4948049..4955358)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Actin;Actin-4 Neighboring gene EB domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Catecholamine receptor polymorphisms affect decision-making in C. elegans. Bendesky A, et al. Nature, 2011 Apr 21. PMID 21412235, Free PMC Article
    2. Neuropeptides amplify and focus the monoaminergic inhibition of nociception in Caenorhabditis elegans. Hapiak V, et al. J Neurosci, 2013 Aug 28. PMID 23986246, Free PMC Article
    3. Trimethylamine modulates dauer formation, neurodegeneration, and lifespan through tyra-3/daf-11 signaling in Caenorhabditis elegans. Khanna A, et al. Aging Cell, 2021 May. PMID 33819374, Free PMC Article
    4. Coordination of behavioral hierarchies during environmental transitions in Caenorhabditis elegans. Vidal-Gadea AG, et al. Worm, 2012 Jan. PMID 23525841, Free PMC Article
    5. An oxytocin-dependent social interaction between larvae and adult C. elegans. Scott E, et al. Sci Rep, 2017 Aug 31. PMID 28860630, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled amine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables octopamine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled serotonin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to nitrogen compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptors family 1 profile domain-containing protein
    NP_001024804.1
    • Confirmed by transcript evidence
    NP_001024805.1
    • Partially confirmed by transcript evidence
    NP_001041275.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4948049..4955358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029633.5 → NP_001024804.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024804.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23013
      Conserved Domains (3) summary
      cd15061
      Location:73 → 272
      7tmA_tyramine_R-like; tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:460 → 490
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:458 → 536
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_001029634.3 → NP_001024805.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024805.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JNP9
      Conserved Domains (3) summary
      cd15061
      Location:101 → 300
      7tmA_tyramine_R-like; tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:488 → 518
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:486 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. NM_001047810.5 → NP_001041275.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041275.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2L6V9
      Conserved Domains (3) summary
      cd15061
      Location:1 → 193
      7tmA_tyramine_R-like; tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:381 → 411
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:379 → 457
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein
    Heading Accession and Version

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