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    H10E21.5 RING-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175169, updated on 9-Dec-2024

    Summary

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    Official Symbol
    H10E21.5
    Official Full Name
    RING-type domain-containing protein
    Primary source
    WormBase:WBGene00019185
    Locus tag
    CELE_H10E21.5
    See related
    AllianceGenome:WB:WBGene00019185
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to several human genes including RNF150 (ring finger protein 150). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See H10E21.5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (20531..23962, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Nuclear hormone receptor family member nhr-80 Neighboring gene Transposase Neighboring gene EF-hand domain-containing protein Neighboring gene Calpain catalytic domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RING-type domain-containing protein
    NP_497129.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      20531..23962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064728.5 → NP_497129.1  RING-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497129.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76671
      Conserved Domains (2) summary
      COG5243
      Location:150 → 325
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd16668
      Location:226 → 273
      RING-H2_GRAIL; RING finger, H2 subclass, found in the GRAIL transmembrane proteins family
    Nucleotide Protein
    Heading Accession and Version

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