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    snx-14 Sorting nexin-12 [ Caenorhabditis elegans ]

    Gene ID: 174997, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snx-14
    Official Full Name
    Sorting nexin-12
    Primary source
    WormBase:WBGene00013011
    Locus tag
    CELE_Y48E1B.14
    See related
    AllianceGenome:WB:WBGene00013011
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in autophagosome maturation. Predicted to be located in membrane. Predicted to be active in late endosome. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 20. Orthologous to human SNX14 (sorting nexin 14). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See snx-14 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (13522939..13531218, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Peptidase_M13_N domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine receptor class epsilon-45 Neighboring gene ncRNA Neighboring gene G domain-containing protein Neighboring gene PIG-P domain-containing protein Neighboring gene WASH complex subunit homolog 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SNX-3 mediates retromer-independent tubular endosomal recycling by opposing EEA-1-facilitated trafficking. Tian Y, et al. PLoS Genet, 2021 Jun. PMID 34081703, Free PMC Article
    2. A pathway for phagosome maturation during engulfment of apoptotic cells. Kinchen JM, et al. Nat Cell Biol, 2008 May. PMID 18425118, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sorting nexin-12
    NP_496844.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13522939..13531218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064443.6 → NP_496844.3  Sorting nexin-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496844.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF63
      Conserved Domains (4) summary
      cd06877
      Location:591 → 708
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      smart00315
      Location:352 → 475
      RGS; Regulator of G protein signalling domain
      pfam08628
      Location:856 → 941
      Nexin_C; Sorting nexin C terminal
      cl02564
      Location:112 → 314
      PXA; PXA domain
    Nucleotide Protein
    Heading Accession and Version

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