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    exc-15 NADP-dependent oxidoreductase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178844, updated on 9-Dec-2024

    Summary

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    Official Symbol
    exc-15
    Official Full Name
    NADP-dependent oxidoreductase domain-containing protein
    Primary source
    WormBase:WBGene00020369
    Locus tag
    CELE_T08H10.1
    See related
    AllianceGenome:WB:WBGene00020369
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aldose reductase (NADPH) activity. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See exc-15 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (4483459..4486543)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene Homeobox domain-containing protein;Homeobox protein unc-62 Neighboring gene Transmembrane protein Neighboring gene Son of sevenless homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease. Taylor RC, et al. J Biol Chem, 2007 May 18. PMID 17371877
    2. Genome sequencing of C. elegans balancer strains reveals previously unappreciated complex genomic rearrangements. Maroilley T, et al. Genome Res, 2023 Jan. PMID 36617680, Free PMC Article
    3. AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane fluidity. Ruiz M, et al. J Biol Chem, 2023 Jun. PMID 37164154, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NADP-dependent oxidoreductase domain-containing protein
    NP_001367925.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4483459..4486543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380633.2 → NP_001367925.1  NADP-dependent oxidoreductase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22352
      Conserved Domains (1) summary
      cd19154
      Location:3 → 306
      AKR_AKR1G1_CeAKR; Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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