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    ckb-4 Choline/ethanolamine kinase [ Caenorhabditis elegans ]

    Gene ID: 184864, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ckb-4
    Official Full Name
    Choline/ethanolamine kinase
    Primary source
    WormBase:WBGene00000514
    Locus tag
    CELE_F22F7.5
    See related
    AllianceGenome:WB:WBGene00000514
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables choline kinase activity. Involved in CDP-choline pathway. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in intellectual disability; megaconial type congenital muscular dystrophy; muscular dystrophy; narcolepsy; and recurrent hypersomnia. Orthologous to human CHKA (choline kinase alpha) and CHKB (choline kinase beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ckb-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (2106398..2109434, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Glycosyltransferase family 92 protein Neighboring gene Glycosyltransferase family 92 protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Glycosyltransferase family 92 protein Neighboring gene B3GNT1, Beta-1,3-N-acetylGucosamiNylTransferase 1, homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization. Gee P, et al. Biochim Biophys Acta, 2003 May 30. PMID 12758145
    2. Development of a transcription-based bioanalytical tool to quantify the toxic potencies of hydrophilic compounds in water using the nematode Caenorhabditis elegans. Karengera A, et al. Ecotoxicol Environ Saf, 2021 Dec 20. PMID 34700171
    3. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables choline kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables choline kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ethanolamine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-choline pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CDP-choline pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in phosphatidylethanolamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Choline/ethanolamine kinase
    NP_503573.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      2106398..2109434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071172.6 → NP_503573.1  Choline/ethanolamine kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503573.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GZF3
      Conserved Domains (2) summary
      PLN02236
      Location:31 → 369
      PLN02236; choline kinase
      cd05156
      Location:43 → 370
      ChoK_euk; Euykaryotic Choline Kinase

    RNA

    1. NR_132528.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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