pig-1 Maternal embryonic leucine zipper kinase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pig-1
Official Full Name: Maternal embryonic leucine zipper kinase
Primary source: WormBase:WBGene00021012
Locus tag: CELE_W03G1.6
See related: AllianceGenome:WB:WBGene00021012
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including generation of neurons; hemidesmosome assembly; and regulation of apoptotic process. Located in centrosome and cytoplasm. Is expressed in several structures, including Q lineage cell; QL; QL.aa; QL.pp; and neurons. Orthologous to human MELK (maternal embryonic leucine zipper kinase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pig-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 11

Sequence:: Chromosome: IV; NC_003282.8 (506731..519457, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NMY-2, TOE-2 and PIG-1 regulate Caenorhabditis elegans asymmetric cell divisions.
Title: NMY-2, TOE-2 and PIG-1 regulate Caenorhabditis elegans asymmetric cell divisions.
PIG-1 MELK-dependent phosphorylation of nonmuscle myosin II promotes apoptosis through CES-1 Snail partitioning.
Title: PIG-1 MELK-dependent phosphorylation of nonmuscle myosin II promotes apoptosis through CES-1 Snail partitioning.
pig-1 MELK acts downstream of ces-1 Snail to cause the neurosecretory motor neuron neuroblast to divide asymmetrically by size and along the correct cell division axis.
Title: Caenorhabditis elegans CES-1 Snail Represses pig-1 MELK Expression To Control Asymmetric Cell Division.
T169 residue in the PIG-1 activation loop is essential for PIG-1 activation by Par-4.
Title: Caenorhabditis elegans PIG-1/MELK acts in a conserved PAR-4/LKB1 polarity pathway to promote asymmetric neuroblast divisions.
PIG-1 promotes shed-cell detachment by preventing the cell-surface expression of cell-adhesion molecules; findings reveal a mechanism for apoptotic cell elimination that is fundamentally distinct from that of canonical programmed cell death
Title: Programmed elimination of cells by caspase-independent cell extrusion in C. elegans.
Results demonstrate that pig-1 regulates asymmetric divisions of neuroblasts that divide to produce an apoptotic cell and either a neural precursor or a neuron.
Title: The C. elegans MELK ortholog PIG-1 regulates cell size asymmetry and daughter cell fate in asymmetric neuroblast divisions.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W03G1.6 (e-PCR)
- UniSTS:319702

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in asymmetric neuroblast division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in asymmetric neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dopaminergic neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hemidesmosome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of apoptotic process involved in development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuroblast development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Maternal embryonic leucine zipper kinase

NP_001023420.2

Confirmed by transcript evidence

NP_001023421.2

Confirmed by transcript evidence

NP_001294353.1

Confirmed by transcript evidence

NP_001294354.1

Confirmed by transcript evidence

NP_001294357.1

Confirmed by transcript evidence

NP_001294358.1

Confirmed by transcript evidence

NP_001368238.1

Confirmed by transcript evidence

NP_001368239.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

506731..519457 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001307424.3 → NP_001294353.1 Maternal embryonic leucine zipper kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294353.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A7WK47, A7WK48, U4PB44, U4PBH9, U4PED2, U4PLZ7, U4PR86, U4PR90

Conserved Domains (4) summary

cd12198
Location:611 → 703

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

smart00220
Location:11 → 265

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14341
Location:284 → 335

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cd14078
Location:7 → 265

STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
NM_001028249.6 → NP_001023420.2 Maternal embryonic leucine zipper kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023420.2

Status: REVIEWED

UniProtKB/Swiss-Prot

U4PR86

Conserved Domains (4) summary

cd12198
Location:608 → 700

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

smart00220
Location:11 → 265

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14341
Location:284 → 335

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cd14078
Location:7 → 265

STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
NM_001380011.1 → NP_001368238.1 Maternal embryonic leucine zipper kinase [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

cd12198
Location:364 → 456

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

cd14341
Location:40 → 91

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cl21453
Location:1 → 21

PKc_like; Protein Kinases, catalytic domain
NM_001307428.3 → NP_001294357.1 Maternal embryonic leucine zipper kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294357.1

Status: REVIEWED

UniProtKB/Swiss-Prot

U4PR86

Conserved Domains (3) summary

cd12198
Location:367 → 459

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

cd14341
Location:40 → 91

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cl21453
Location:1 → 21

PKc_like; Protein Kinases, catalytic domain
NM_001028250.5 → NP_001023421.2 Maternal embryonic leucine zipper kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023421.2

Status: REVIEWED

UniProtKB/Swiss-Prot

U4PR86

Conserved Domains (4) summary

smart00220
Location:11 → 265

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14341
Location:284 → 335

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cd14078
Location:7 → 265

STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase

cl17070
Location:608 → 680

AMPKA_C_like; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains
NM_001307425.1 → NP_001294354.1 Maternal embryonic leucine zipper kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294354.1

Status: REVIEWED

UniProtKB/Swiss-Prot

U4PR86

Conserved Domains (4) summary

smart00220
Location:11 → 265

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14341
Location:284 → 335

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cd14078
Location:7 → 265

STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase

cl17070
Location:611 → 683

AMPKA_C_like; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains
NM_001380012.1 → NP_001368239.1 Maternal embryonic leucine zipper kinase [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

cd14341
Location:40 → 91

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cl17070
Location:364 → 436

AMPKA_C_like; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains

cl21453
Location:1 → 21

PKc_like; Protein Kinases, catalytic domain
NM_001307429.3 → NP_001294358.1 Maternal embryonic leucine zipper kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294358.1

Status: REVIEWED

UniProtKB/Swiss-Prot

U4PR86

Conserved Domains (3) summary

cd14341
Location:40 → 91

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cl17070
Location:367 → 439

AMPKA_C_like; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains

cl21453
Location:1 → 21

PKc_like; Protein Kinases, catalytic domain