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    chhy-1 Chondroitin hydrolase [ Caenorhabditis elegans ]

    Gene ID: 174383, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chhy-1
    Official Full Name
    Chondroitin hydrolase
    Primary source
    WormBase:WBGene00011923
    Locus tag
    CELE_T22C8.2
    See related
    AllianceGenome:WB:WBGene00011923
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables hexosaminidase activity. Involved in chondroitin sulfate catabolic process. Is expressed in PLML; PLMR; head; intestinal cell; and vulva. Human ortholog(s) of this gene implicated in mucopolysaccharidosis and mucopolysaccharidosis IX. Orthologous to several human genes including HYAL2 (hyaluronidase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See chhy-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (8614546..8617616, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Centrosomal protein CEP104 N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene C2H2-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hypotheses on the evolution of hyaluronan: a highly ironic acid. Csoka AB, et al. Glycobiology, 2013 Apr. PMID 23315448, Free PMC Article
    2. Identification of a novel chondroitin hydrolase in Caenorhabditis elegans. Kaneiwa T, et al. J Biol Chem, 2008 May 30. PMID 18390555, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hexosaminidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hyalurononglucosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chondroitin sulfate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in hyaluronan catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Chondroitin hydrolase
    NP_495830.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8614546..8617616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063429.5 → NP_495830.1  Chondroitin hydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495830.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECE8
      Conserved Domains (1) summary
      pfam01630
      Location:38 → 352
      Glyco_hydro_56; Hyaluronidase
    Nucleotide Protein
    Heading Accession and Version

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