git-1 Arf-GAP domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: git-1
Official Full Name: Arf-GAP domain-containing protein
Primary source: WormBase:WBGene00008805
Locus tag: CELE_F14F3.2
See related: AllianceGenome:WB:WBGene00008805
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in gonad morphogenesis and inductive cell migration. Located in hemidesmosome and presynaptic active zone. Is expressed in body wall musculature; hypodermis; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to several human genes including GIT2 (GIT ArfGAP 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See git-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 14

Sequence:: Chromosome: X; NC_003284.9 (10524898..10528452)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuron tracing and quantitative analyses of dendritic architecture reveal symmetrical three-way-junctions and phenotypes of git-1 in C. elegans.
Title: Neuron tracing and quantitative analyses of dendritic architecture reveal symmetrical three-way-junctions and phenotypes of git-1 in C. elegans.
GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans
Title: A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F14F3.2 (e-PCR)
- UniSTS:306021

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	IEA Inferred from Electronic Annotation more info
involved_in gonad morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gonad morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inductive cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ARF protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle recycling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in hemidesmosome	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Arf-GAP domain-containing protein

NP_509761.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

10524898..10528452

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077360.9 → NP_509761.2 Arf-GAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509761.2

Status: REVIEWED

UniProtKB/TrEMBL

Q19467

Conserved Domains (5) summary

smart00555
Location:326 → 356

GIT; Helical motif in the GIT family of ADP-ribosylation factor GTPase-activating proteins

smart00105
Location:7 → 127

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:122 → 212

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam13857
Location:152 → 207

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:165 → 197

ANK; ANK repeat [structural motif]