klp-15 Kinesin motor domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: klp-15
Official Full Name: Kinesin motor domain-containing protein
Primary source: WormBase:WBGene00002225
Locus tag: CELE_M01E11.6
See related: AllianceGenome:WB:WBGene00002225
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables minus-end-directed microtubule motor activity. Involved in chromosome segregation and microtubule-based movement. Predicted to be located in cytoskeleton. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Is expressed in germ line and hypodermis. Orthologous to human KIFC1 (kinesin family member C1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See klp-15 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (5577070..5579194, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we report insights into the principles underlying this specialized form of cell division, through studies of C. elegans KLP-15 and KLP-16, two highly homologous members of the kinesin-14 family of minus-end-directed kinesins. These proteins localize to the acentriolar oocyte spindle and promote microtubule bundling during spindle assembly.
Title: Interplay between microtubule bundling and sorting factors ensures acentriolar spindle stability during C. elegans oocyte meiosis.
Bacterially expressed KLP-15 constructs with different length extensions preceding the motor domain are used to determine in vitro ATPase activity, microtubule binding, oligomeric state, microtubule gliding activity, and direction of movement.
Title: Essential kinesins: characterization of Caenorhabditis elegans KLP-15.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C41G7.2 (e-PCR)
- UniSTS:309288

M01E11.2 (e-PCR)
- UniSTS:311951

M01E11.6 (e-PCR)
- UniSTS:311955

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables minus-end-directed microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Kinesin motor domain-containing protein

NP_491633.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5577070..5579194 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059232.5 → NP_491633.1 Kinesin motor domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491633.1

Status: REVIEWED

UniProtKB/TrEMBL

P91400, Q9NL41

Conserved Domains (4) summary

PHA03378
Location:27 → 153

PHA03378; EBNA-3B; Provisional

cd00106
Location:248 → 564

KISc; Kinesin motor domain

pfam12718
Location:147 → 242

Tropomyosin_1; Tropomyosin like

pfam16326
Location:147 → 193

ABC_tran_CTD; ABC transporter C-terminal domain