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    ins-6 putative insulin-like peptide beta-type 5 [ Caenorhabditis elegans ]

    Gene ID: 191687, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ins-6
    Official Full Name
    putative insulin-like peptide beta-type 5
    Primary source
    WormBase:WBGene00002089
    Locus tag
    CELE_ZK84.6
    See related
    AllianceGenome:WB:WBGene00002089
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables insulin receptor binding activity. Involved in several processes, including insulin receptor signaling pathway; negative regulation of dauer entry; and olfactory learning. Predicted to be located in extracellular space. Is expressed in several structures, including coelomocyte; head muscle; neurons; somatic nervous system; and uterus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ins-6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003280.10 (6000436..6001009)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative insulin-like peptide beta-type 1 Neighboring gene Putative insulin-like peptide beta-type 6 Neighboring gene ncRNA Neighboring gene Ovule protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides. Artan M, et al. Genes Dev, 2016 May 1. PMID 27125673, Free PMC Article
    2. From genes to circuits and behaviors: Neuropeptides expand the coding potential of the nervous system. Leinwand SG, et al. Worm, 2014. PMID 25254145, Free PMC Article
    3. A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor. Hua QX, et al. Genes Dev, 2003 Apr 1. PMID 12654724, Free PMC Article
    4. L1 arrest, daf-16/FoxO and nonautonomous control of post-embryonic development. Kaplan RE, et al. Worm, 2016 Apr-Jun. PMID 27383290, Free PMC Article
    5. Specific insulin-like peptides encode sensory information to regulate distinct developmental processes. Cornils A, et al. Development, 2011 Mar. PMID 21343369, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables insulin receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to salt IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to salt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of dauer entry IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative insulin-like peptide beta-type 5
    NP_495198.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6000436..6001009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062797.3 → NP_495198.1  putative insulin-like peptide beta-type 5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495198.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P56174, Q23631
      Conserved Domains (1) summary
      pfam03488
      Location:65 → 112
      Ins_beta; Nematode insulin-related peptide beta type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56174.1

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