U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cku-80 ATP-dependent DNA helicase II subunit 2;Ku C-terminal domain-containing protein;Ku_PK_bind domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175578, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cku-80
    Official Full Name
    ATP-dependent DNA helicase II subunit 2;Ku C-terminal domain-containing protein;Ku_PK_bind domain-containing protein
    Primary source
    WormBase:WBGene00000520
    Locus tag
    CELE_R07E5.8
    See related
    AllianceGenome:WB:WBGene00000520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable telomeric DNA binding activity. Predicted to contribute to double-stranded DNA binding activity. Involved in DNA repair. Predicted to be located in nucleus. Predicted to be part of Ku70:Ku80 complex. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; multiple myeloma; and rectum cancer. Orthologous to human XRCC5 (X-ray repair cross complementing 5). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cku-80 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    13
    Sequence:
    Chromosome: III; NC_003281.10 (4419848..4423347)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene MYND-type domain-containing protein Neighboring gene Vacuolar ATPase assembly integral membrane protein VMA21 homolog Neighboring gene Uncharacterized protein Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Ala

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Ku86 preserves chromatin integrity in cells adapted to high NaCl. Dmitrieva NI, et al. Proc Natl Acad Sci U S A, 2005 Jul 26. PMID 16027367, Free PMC Article
    2. Targeted engineering of the Caenorhabditis elegans genome following Mos1-triggered chromosomal breaks. Robert V, et al. EMBO J, 2007 Jan 10. PMID 17159906, Free PMC Article
    3. Maintenance of Genome Integrity by Mi2 Homologs CHD-3 and LET-418 in Caenorhabditis elegans. Turcotte CA, et al. Genetics, 2018 Mar. PMID 29339410, Free PMC Article
    4. The C. elegans ortholog of mammalian Ku70, interacts with insulin-like signaling to modulate stress resistance and life span. McColl G, et al. FASEB J, 2005 Oct. PMID 16099946, Free PMC Article
    5. NHJ-1 Is Required for Canonical Nonhomologous End Joining in Caenorhabditis elegans. Vujin A, et al. Genetics, 2020 Jul. PMID 32457132, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Ku70:Ku80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ku70:Ku80 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ATP-dependent DNA helicase II subunit 2;Ku C-terminal domain-containing protein;Ku_PK_bind domain-containing protein
    NP_001309438.1
    • Confirmed by transcript evidence
    NP_001309599.1
    • Confirmed by transcript evidence
    NP_001309600.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4419848..4423347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001322514.3 → NP_001309438.1  ATP-dependent DNA helicase II subunit 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21829
      Conserved Domains (2) summary
      cd00198
      Location:12 → 178
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cd00873
      Location:229 → 542
      KU80; Ku-core domain, Ku80 subfamily; Ku80 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the ...

    2. NM_001322520.3 → NP_001309599.1  Ku_PK_bind domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBI3
      Conserved Domains (1) summary
      cl02666
      Location:1 → 161
      KU; Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen ...

    3. NM_001322524.3 → NP_001309600.1  Ku C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MCF2
      Conserved Domains (1) summary
      cl02666
      Location:1 → 56
      KU; Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen ...
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous