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    lgc-33 Neurotransmitter-gated ion-channel ligand-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176910, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lgc-33
    Official Full Name
    Neurotransmitter-gated ion-channel ligand-binding domain-containing protein
    Primary source
    WormBase:WBGene00021941
    Locus tag
    CELE_Y55F3BR.4
    See related
    AllianceGenome:WB:WBGene00021941
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in chemical synaptic transmission; monoatomic ion transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane and postsynapse. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in neuron projection; plasma membrane; and synapse. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lgc-33 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (845498..848872)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene SHSP domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene Ankyrin repeat and LEM domain-containing protein 2 homolog Neighboring gene Ground-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cys-loop ligand-gated ion channel gene superfamily of the nematode, Caenorhabditis elegans. Jones AK, et al. Invert Neurosci, 2008 Mar. PMID 18288508, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Neurotransmitter-gated ion-channel ligand-binding domain-containing protein
    NP_001294461.1
    • Confirmed by transcript evidence
    NP_500000.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      845498..848872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307532.3 → NP_001294461.1  Neurotransmitter-gated ion-channel ligand-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294461.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBJ1
      Conserved Domains (3) summary
      TIGR00860
      Location:18 → 232
      LIC; Cation transporter family protein
      cd03558
      Location:154 → 168
      LGIC_ECD; Cys-loop [structural motif]
      cl28912
      Location:87 → 173
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

    2. NM_067599.4 → NP_500000.3  Neurotransmitter-gated ion-channel ligand-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500000.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WTK7
      Conserved Domains (3) summary
      TIGR00860
      Location:18 → 232
      LIC; Cation transporter family protein
      cd03558
      Location:154 → 168
      LGIC_ECD; Cys-loop [structural motif]
      cl28912
      Location:87 → 173
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
    Nucleotide Protein
    Heading Accession and Version

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