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    mtm-3 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 [ Caenorhabditis elegans ]

    Gene ID: 175490, updated on 9-Dec-2024

    Summary

    Official Symbol
    mtm-3
    Official Full Name
    Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3
    Primary source
    WormBase:WBGene00003476
    Locus tag
    CELE_T24A11.1
    See related
    AllianceGenome:WB:WBGene00003476
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables inositol bisphosphate phosphatase activity and phosphatidylinositol phosphate phosphatase activity. Involved in several processes, including determination of adult lifespan; positive regulation of autophagosome maturation; and regulation of endocytosis. Located in cytoplasm. Is expressed in body wall musculature and head neurons. Orthologous to several human genes including MTMR3 (myotubularin related protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See mtm-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (3789982..3800467, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene adenylate cyclase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene X-BoX promoter element regulated Neighboring gene Zinc metalloproteinase nas-26

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity  
    enables inositol bisphosphate phosphatase activity PubMed 
    enables lipid binding  
    enables metal ion binding  
    enables phosphatidylinositol trisphosphate phosphatase activity PubMed 
    enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity PubMed 
    enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity  
    enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity  
    enables phosphatidylinositol-3,5-bisphosphate phosphatase activity  
    enables phosphatidylinositol-3-phosphate phosphatase activity  
    enables phosphatidylinositol-3-phosphate phosphatase activity PubMed 
    enables phosphatidylinositol-3-phosphate phosphatase activity  
    enables phosphatidylinositol-3-phosphate phosphatase activity  
    enables protein tyrosine phosphatase activity  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in membrane  

    General protein information

    Preferred Names
    Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3
    NP_001022794.2
    • Partially confirmed by transcript evidence
    NP_497766.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3789982..3800467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027623.7 → NP_001022794.2  Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022794.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8NBE6, Q22712, Q9U360, Q9XTK4
      Conserved Domains (2) summary
      smart00064
      Location:814 → 883
      FYVE; Protein present in Fab1, YOTB, Vac1, and EEA1
      pfam06602
      Location:258 → 574
      Myotub-related; Myotubularin-like phosphatase domain
    2. NM_065365.10 → NP_497766.3  Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497766.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22712
      Conserved Domains (2) summary
      smart00064
      Location:810 → 879
      FYVE; Protein present in Fab1, YOTB, Vac1, and EEA1
      pfam06602
      Location:254 → 570
      Myotub-related; Myotubularin-like phosphatase domain
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