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    cle-1 Collagen alpha-1(XVIII) chain;Endostatin domain-containing protein;Fibronectin type-III domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172678, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cle-1
    Official Full Name
    Collagen alpha-1(XVIII) chain;Endostatin domain-containing protein;Fibronectin type-III domain-containing protein
    Primary source
    WormBase:WBGene00000527
    Locus tag
    CELE_C36B1.1
    See related
    AllianceGenome:WB:WBGene00000527
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be an extracellular matrix structural constituent conferring tensile strength. Involved in several processes, including cholinergic synaptic transmission; generation of neurons; and inductive cell migration. Located in basement membrane and cell junction. Is expressed in several structures, including basal lamina; head mesodermal cell; neurons; smooth muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in primary angle-closure glaucoma. Orthologous to human COL15A1 (collagen type XV alpha 1 chain) and COL18A1 (collagen type XVIII alpha 1 chain). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cle-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    25
    Sequence:
    Chromosome: I; NC_003279.8 (8705668..8724279, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene MBD domain-containing protein;Pre-mRNA-splicing factor SLU7;Pre-mRNA-splicing factor SYF2 Neighboring gene Craniofacial development protein 1 Neighboring gene Proteasome subunit beta Neighboring gene TATA box-binding protein-like 1 Neighboring gene Cyclin-dependent kinase 8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Proteasome subunit alpha type-7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The NC1/endostatin domain of Caenorhabditis elegans type XVIII collagen affects cell migration and axon guidance. Ackley BD, et al. J Cell Biol, 2001 Mar 19. PMID 11257122, Free PMC Article
    2. The multiple functions of collagen XVIII in development and disease. Seppinen L, et al. Matrix Biol, 2011 Mar. PMID 21163348
    3. The basement membrane components nidogen and type XVIII collagen regulate organization of neuromuscular junctions in Caenorhabditis elegans. Ackley BD, et al. J Neurosci, 2003 May 1. PMID 12736328, Free PMC Article
    4. Selective assembly of fibulin-1 splice variants reveals distinct extracellular matrix networks and novel functions for perlecan/UNC-52 splice variants. Muriel JM, et al. Dev Dyn, 2006 Oct. PMID 16804890
    5. Caenorhabditis elegans teneurin, ten-1, is required for gonadal and pharyngeal basement membrane integrity and acts redundantly with integrin ina-1 and dystroglycan dgn-1. Trzebiatowska A, et al. Mol Biol Cell, 2008 Sep. PMID 18632986, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent conferring tensile strength IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inductive cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Collagen alpha-1(XVIII) chain;Endostatin domain-containing protein;Fibronectin type-III domain-containing protein
    NP_492358.3
    • Confirmed by transcript evidence
    NP_740896.2
    • Confirmed by transcript evidence
    NP_740897.1
    • Confirmed by transcript evidence
    NP_740898.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8705668..8724279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170906.6 → NP_740898.1  Endostatin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740898.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDQ4
      Conserved Domains (2) summary
      pfam01391
      Location:182 → 225
      Collagen; Collagen triple helix repeat (20 copies)
      cd00247
      Location:462 → 630
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...

    2. NM_170904.3 → NP_740896.2  Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740896.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF89, Q9U9K7
      Conserved Domains (4) summary
      pfam01391
      Location:669 → 710
      Collagen; Collagen triple helix repeat (20 copies)
      cd00063
      Location:33 → 109
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00247
      Location:950 → 1118
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      cl22861
      Location:422 → 583
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    3. NM_170905.3 → NP_740897.1  Collagen alpha-1(XVIII) chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740897.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDV5
      Conserved Domains (3) summary
      pfam01391
      Location:310 → 353
      Collagen; Collagen triple helix repeat (20 copies)
      cd00247
      Location:590 → 758
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      cl22861
      Location:62 → 223
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    4. NM_059957.5 → NP_492358.3  Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492358.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGA4, Q9U9K7
      Conserved Domains (4) summary
      pfam01391
      Location:706 → 747
      Collagen; Collagen triple helix repeat (20 copies)
      cd00063
      Location:33 → 109
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00247
      Location:987 → 1155
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      cl22861
      Location:422 → 583
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    Nucleotide Protein
    Heading Accession and Version

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