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    syx-17 t-SNARE coiled-coil homology domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172663, updated on 9-Dec-2024

    Summary

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    Official Symbol
    syx-17
    Official Full Name
    t-SNARE coiled-coil homology domain-containing protein
    Primary source
    WormBase:WBGene00012150
    Locus tag
    CELE_VF39H2L.1
    See related
    AllianceGenome:WB:WBGene00012150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in several processes, including intracellular protein transport; vesicle docking; and vesicle fusion. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in autophagosome membrane; endomembrane system; and plasma membrane. Orthologous to human STX17 (syntaxin 17). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See syx-17 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (8644460..8646304)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Microfibrillar-associated protein 1 Neighboring gene GCF C-terminal domain-containing protein Neighboring gene Peptidyl-prolyl cis-trans isomerase sig-7 Neighboring gene SPSAKWMRF-amide 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MitoSNARE Assembly and Disassembly Factors Regulate Basal Autophagy and Aging in C. elegans. Gkikas I, et al. Int J Mol Sci, 2023 Feb 20. PMID 36835643, Free PMC Article
    2. Caenorhabditis elegans SNAP-29 is required for organellar integrity of the endomembrane system and general exocytosis in intestinal epithelial cells. Sato M, et al. Mol Biol Cell, 2011 Jul 15. PMID 21613542, Free PMC Article
    3. Depletion of syntaxins in the early Caenorhabditis elegans embryo reveals a role for membrane fusion events in cytokinesis. Jantsch-Plunger V, et al. Curr Biol, 1999 Jul 15. PMID 10421575
    4. The SM protein VPS-45 is required for RAB-5-dependent endocytic transport in Caenorhabditis elegans. Gengyo-Ando K, et al. EMBO Rep, 2007 Feb. PMID 17235359, Free PMC Article
    5. Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans. Konstantinidis G, et al. Cells, 2021 Mar 21. PMID 33800981, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    t-SNARE coiled-coil homology domain-containing protein
    NP_492342.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8644460..8646304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059941.4 → NP_492342.1  t-SNARE coiled-coil homology domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492342.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62387
      Conserved Domains (1) summary
      cl22856
      Location:132 → 188
      SNARE; SNARE motif
    Nucleotide Protein
    Heading Accession and Version

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