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    rsa-2 Regulator of spindle assembly protein 2 [ Caenorhabditis elegans ]

    Gene ID: 176536, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rsa-2
    Official Full Name
    Regulator of spindle assembly protein 2
    Primary source
    WormBase:WBGene00012972
    Locus tag
    CELE_Y48A6B.11
    See related
    AllianceGenome:WB:WBGene00012972
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables beta-catenin binding activity and protein-macromolecule adaptor activity. Involved in embryonic digestive tract development; mitotic spindle organization; and protein localization to organelle. Located in centrosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rsa-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (11063479..11068759)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Enoyl-[acyl-carrier-protein] reductase, mitochondrial Neighboring gene Protein lilliputian;Suppressor of PAr-Two defect Neighboring gene ncRNA Neighboring gene tRNA-Pro Neighboring gene tRNA-Pro Neighboring gene AMP-dependent synthetase/ligase domain-containing protein Neighboring gene Seven TM Receptor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans pericentriolar material components SPD-2 and SPD-5 are monomeric in the cytoplasm before incorporation into the PCM matrix. Wueseke O, et al. Mol Biol Cell, 2014 Oct 1. PMID 25103243, Free PMC Article
    2. Centrosome-Associated Degradation Limits β-Catenin Inheritance by Daughter Cells after Asymmetric Division. Vora S, et al. Curr Biol, 2015 Apr 20. PMID 25819561
    3. The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly. Schlaitz AL, et al. Cell, 2007 Jan 12. PMID 17218259, Free PMC Article
    4. Wnt Signaling Polarizes C. elegans Asymmetric Cell Divisions During Development. Lam AK, et al. Results Probl Cell Differ, 2017. PMID 28409301, Free PMC Article
    5. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic digestive tract development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to organelle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Regulator of spindle assembly protein 2
    NP_001022886.1
    • Confirmed by transcript evidence
    NP_001382698.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11063479..11068759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001395774.1 → NP_001382698.1  Regulator of spindle assembly protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDA1, G5EFV3
      UniProtKB/TrEMBL
      A0A7R9SUN5

    2. NM_001027715.3 → NP_001022886.1  Regulator of spindle assembly protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022886.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDA1, G5EFV3
    Nucleotide Protein
    Heading Accession and Version

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