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    aip-1 AN1-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179898, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aip-1
    Official Full Name
    AN1-type domain-containing protein
    Primary source
    WormBase:WBGene00000097
    Locus tag
    CELE_F58E10.4
    See related
    AllianceGenome:WB:WBGene00000097
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable zinc ion binding activity. Involved in cellular response to misfolded protein and response to arsenic-containing substance. Located in cytoplasm and nucleus. Is expressed in several structures, including excretory cell; intestine; pharynx; somatic gonad; and tail. Orthologous to human ZFAND2A (zinc finger AN1-type containing 2A) and ZFAND2B (zinc finger AN1-type containing 2B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aip-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (14012333..14013644)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene CRAL-TRIO domain-containing protein;DUF1336 domain-containing protein;Uncharacterized protein Neighboring gene dietary restriction over expressed Neighboring gene RNA helicase Neighboring gene GATA-type domain-containing protein Neighboring gene Serpentine Receptor, class H Neighboring gene Metallothionein-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model. Hassan WM, et al. Hum Mol Genet, 2009 Aug 1. PMID 19414486, Free PMC Article
    2. Arsenite-inducible RNA-associated protein (AIRAP) protects cells from arsenite toxicity. Sok J, et al. Cell Stress Chaperones, 2001 Jan. PMID 11525245, Free PMC Article
    3. Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans. Yun C, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18467495, Free PMC Article
    4. An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity. Stanhill A, et al. Mol Cell, 2006 Sep 15. PMID 16973439
    5. Genetic redundancy in endoderm specification within the genus Caenorhabditis. Maduro MF, et al. Dev Biol, 2005 Aug 15. PMID 15979606

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. aip-1 deficient worms have reduced longevity.
      Title: Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.
    2. Results show that cell stress triggers aip-1 expression by both skn-1-dependent and -independent pathways.
      Title: skn-1-Dependent and -independent regulation of aip-1 expression following metabolic stress in Caenorhabditis elegans.
    3. AIP-1 mutant lacking the predicted farnesylation site failed to protect against Abeta toxicity.
      Title: AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to misfolded protein IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to arsenic-containing substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AN1-type domain-containing protein
    NP_506479.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14012333..14013644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074078.4 → NP_506479.1  AN1-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506479.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6R023, Q9XUW8
      Conserved Domains (1) summary
      pfam01428
      Location:98 → 133
      zf-AN1; AN1-like Zinc finger
    Nucleotide Protein
    Heading Accession and Version

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