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    rme-4 UDENN domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 185870, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rme-4
    Official Full Name
    UDENN domain-containing protein
    Primary source
    WormBase:WBGene00004375
    Locus tag
    CELE_F46F6.1
    See related
    AllianceGenome:WB:WBGene00004375
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol phosphate binding activity. Involved in endocytic recycling. Located in clathrin-coated pit. Is expressed widely. Orthologous to human DENND1A (DENN domain containing 1A); DENND1B (DENN domain containing 1B); and DENND1C (DENN domain containing 1C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rme-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (10373232..10377769, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene DM10 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Intraflagellar transport protein 46 homolog Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RAB-35 and ARF-6 GTPases Mediate Engulfment and Clearance Following Linker Cell-Type Death. Kutscher LM, et al. Dev Cell, 2018 Oct 22. PMID 30220571, Free PMC Article
    2. The small GTPase RAB-35 defines a third pathway that is required for the recognition and degradation of apoptotic cells. Haley R, et al. PLoS Genet, 2018 Aug. PMID 30138370, Free PMC Article
    3. Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein. Sato M, et al. EMBO J, 2008 Apr 23. PMID 18354496, Free PMC Article
    4. Chronic temperature stress inhibits reproduction and disrupts endocytosis via chaperone titration in Caenorhabditis elegans. Plagens RN, et al. BMC Biol, 2021 Apr 15. PMID 33858388, Free PMC Article
    5. Temporally regulated cell migration is sensitive to variation in body size. Dubois C, et al. Development, 2021 Mar 5. PMID 33593818, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UDENN domain-containing protein
    NP_001359519.1
    • Confirmed by transcript evidence
    NP_509739.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      10373232..10377769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373469.3 → NP_001359519.1  UDENN domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K7A5
      Conserved Domains (3) summary
      smart00801
      Location:315 → 383
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:91 → 282
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:12 → 86
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    2. NM_077338.6 → NP_509739.1  UDENN domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509739.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECW9
      Conserved Domains (3) summary
      smart00801
      Location:315 → 383
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:91 → 282
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:12 → 86
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    Nucleotide Protein
    Heading Accession and Version

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