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    inx-18 Innexin [ Caenorhabditis elegans ]

    Gene ID: 182801, updated on 9-Dec-2024

    Summary

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    Official Symbol
    inx-18
    Official Full Name
    Innexin
    Primary source
    WormBase:WBGene00002140
    Locus tag
    CELE_C18H7.2
    See related
    AllianceGenome:WB:WBGene00002140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable gap junction channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Located in gap junction. Is expressed in body wall musculature; g1; head neurons; and interneuron. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See inx-18 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (606355..614062)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Methyltransferase domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene VWFA domain-containing protein Neighboring gene tRNA-Val Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. INX-18 and INX-19 play distinct roles in electrical synapses that modulate aversive behavior in Caenorhabditis elegans. Voelker L, et al. PLoS Genet, 2019 Oct. PMID 31658255, Free PMC Article
    2. Six innexins contribute to electrical coupling of C. elegans body-wall muscle. Liu P, et al. PLoS One, 2013. PMID 24130800, Free PMC Article
    3. PRC1 chromatin factors strengthen the consistency of neuronal cell fate specification and maintenance in C. elegans. Bordet G, et al. PLoS Genet, 2022 May. PMID 35604893, Free PMC Article
    4. The Caenorhabditis elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells. Barnes TM, et al. J Neurochem, 1997 Dec. PMID 9375655
    5. The role of gap junctions in Caenorhabditis elegans oocyte maturation and fertilization. Whitten SJ, et al. Dev Biol, 2007 Jan 15. PMID 16982048

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in gap junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Innexin
    NP_741294.1
    • Confirmed by transcript evidence
    NP_741295.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      606355..614062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171246.5 → NP_741294.1  Innexin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741294.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYH7
      Conserved Domains (1) summary
      pfam00876
      Location:25 → 374
      Innexin; Innexin

    2. NM_171247.6 → NP_741295.1  Innexin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741295.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MXG8
      Conserved Domains (1) summary
      pfam00876
      Location:25 → 374
      Innexin; Innexin
    Nucleotide Protein
    Heading Accession and Version

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