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    clhm-1 Calcium homeostasis modulator protein [ Caenorhabditis elegans ]

    Gene ID: 183429, updated on 9-Dec-2024

    Summary

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    Official Symbol
    clhm-1
    Official Full Name
    Calcium homeostasis modulator protein
    Primary source
    WormBase:WBGene00016626
    Locus tag
    CELE_C44B7.4
    See related
    AllianceGenome:WB:WBGene00016626
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables voltage-gated calcium channel activity. Involved in ATP export; calcium ion transmembrane transport; and regulation of locomotion. Located in non-motile cilium and plasma membrane. Is expressed in body wall musculature; head; sensory neurons; and spermatheca. Orthologous to several human genes including CALHM5 (calcium homeostasis modulator family member 5) and CALHM6 (calcium homeostasis modulator family member 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See clhm-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (6868946..6871009, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Amino acid transporter transmembrane domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cryo-electron microscopy structure of CLHM1 ion channel from Caenorhabditis elegans. Yang W, et al. Protein Sci, 2020 Aug. PMID 32557855, Free PMC Article
    2. The NH(2) terminus regulates voltage-dependent gating of CALHM ion channels. Tanis JE, et al. Am J Physiol Cell Physiol, 2017 Aug 1. PMID 28515089, Free PMC Article
    3. Calcium homeostasis modulator (CALHM) ion channels. Ma Z, et al. Pflugers Arch, 2016 Mar. PMID 26603282, Free PMC Article
    4. Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies. Demura K, et al. Sci Adv, 2020 Jul. PMID 32832629, Free PMC Article
    5. Suppression of Selective Voltage-Gated Calcium Channels Alleviates Neuronal Degeneration and Dysfunction through Glutathione S-Transferase-Mediated Oxidative Stress Resistance in a Caenorhabditis elegans Model of Alzheimer's Disease. Zheng Z, et al. Oxid Med Cell Longev, 2022. PMID 36600949, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cryo-electron microscopy structure of CLHM1 ion channel from Caenorhabditis elegans.
      Title: Cryo-electron microscopy structure of CLHM1 ion channel from Caenorhabditis elegans.
    2. Mutation of ceCLHM-1 valine 9 and glutamine 13 altered half-maximal activation and voltage dependence, respectively, in 0 Ca(2+) In 2 mM Ca(2+)o, ceCLHM-1 NH2-terminal deletion and point mutant channels closed completely at hyperpolarized voltages with apparent affinity for Ca(2+)o indistinguishable from wild-type ceCLHM-1
      Title: The NH(2) terminus regulates voltage-dependent gating of CALHM ion channels.
    3. Our data show that CLHM-1 is a functionally conserved ion channel that plays an important but potentially toxic role in excitable cell function.
      Title: CLHM-1 is a functionally conserved and conditionally toxic Ca2+-permeable ion channel in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP export IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Calcium homeostasis modulator protein
    NP_495403.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6868946..6871009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063002.6 → NP_495403.2  Calcium homeostasis modulator protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495403.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18593
      Conserved Domains (1) summary
      pfam14798
      Location:10 → 262
      Ca_hom_mod; Calcium homeostasis modulator
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18593.2

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