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    inft-2 FH2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179786, updated on 9-Dec-2024

    Summary

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    Official Symbol
    inft-2
    Official Full Name
    FH2 domain-containing protein
    Primary source
    WormBase:WBGene00008848
    Locus tag
    CELE_F15B9.4
    See related
    AllianceGenome:WB:WBGene00008848
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in actin filament polymerization. Predicted to be active in actin filament. Is expressed in excretory cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See inft-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (13002317..13006987)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Fatty-acid and retinol-binding protein 1 Neighboring gene Fatty-acid and retinol-binding protein 1 Neighboring gene DUF148 domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Ala Neighboring gene TPM domain-containing protein Neighboring gene Peptidase S1 domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A network of conserved formins, regulated by the guanine exchange factor EXC-5 and the GTPase CDC-42, modulates tubulogenesis in vivo. Shaye DD, et al. Development, 2016 Nov 15. PMID 27697907, Free PMC Article
    2. Z-line formins promote contractile lattice growth and maintenance in striated muscles of C. elegans. Mi-Mi L, et al. J Cell Biol, 2012 Jul 9. PMID 22753896, Free PMC Article
    3. FHOD-1 is the only formin in Caenorhabditis elegans that promotes striated muscle growth and Z-line organization in a cell autonomous manner. Sundaramurthy S, et al. Cytoskeleton (Hoboken), 2020 Oct. PMID 33103378, Free PMC Article
    4. Functional importance of an inverted formin C-terminal tail at morphologically dynamic epithelial junctions. Hegsted A, et al. Cytoskeleton (Hoboken), 2019 Apr. PMID 31215743, Free PMC Article
    5. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FH2 domain-containing protein
    NP_506253.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13002317..13006987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073852.9 → NP_506253.4  FH2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506253.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19479
      Conserved Domains (1) summary
      cl19758
      Location:597 → 975
      FH2; Formin Homology 2 Domain
    Nucleotide Protein
    Heading Accession and Version

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